3种β_1受体阻滞剂在冠状动脉CT检查中应用的比较

Comparison of The Effectiveness of Oral Different β1-adrenoceptor Blockers in Patients on Preparation of Coronary Computed Tomographic Angiography(CTA)

目的:比较口服美托洛尔、阿替洛尔、比索洛尔3种β1阻滞剂在冠状动脉CT检查中的应用。方法:135例窦性心率≥66次/m in患者随机分为美托洛尔组、阿替洛尔组、比索洛尔组各45例,分别口服美托洛尔50 mg、阿替洛尔50 mg、比索洛尔10 mg后,监测心率变化。结果:比索洛尔组服药后90 m in内92%患者达目标心率,多于其他两组(P<0.01),但耗时较长(P<0.01)。结论:3组患者服药后均可快速、有效、安全地减慢心率,使心率过快患者顺利完成冠脉CT检查。比索洛尔控制心率作用较强,但起效较慢。

Objective：To compare the effectiveness of oral different β1-adrenoceptor blockers in patients on preparation of coronary computed tomographic angiography（CTA）.Methods：135 patients with scheduled for coronary CTA and heart rate（HR）≥66/min were picked out randomly and then divided up into metoprolol group,atenolol group and bisoprolol group averagely.HR was monitored after metoprolol（50 mg）,atenolol（50 mg） or bisoprolol（10 mg） was buceally taken.Results：90 min later,92% patients reached the target HR（≤65/min） after administration with bisoprolol, but these patients took much more time than the patients in other two groups （P 〈 0. 01 ）. Conclusions： Metoprolol, atenolol or bisoprolol all are effective, rapid and safe in decreasing HR, which is benefit for patients scheduled for coronary CTA.