摘要
目的观察辛伐他汀对慢性心衰的作用。方法74例慢性心力衰竭患者,随机分为辛伐他汀治疗组(42例)和对照组(31例),对照组给予强心、利尿、扩血管治疗,治疗组在此基础上加用辛伐他汀,剂量为20mg,每晚1次,疗程6个月,测定左室射血分数(LVEF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD),统计2组治疗后症状改善率、再住院率、死亡率。结果辛伐他汀治疗组与对照组比较,治疗后2组左室射血分数均有所提高,左室收缩末内径均有缩小,但辛伐他汀组明显,与对照组比较差异有统计学意义;治疗后与治疗前比较,辛伐他汀组症状改善率、心衰再住院率、死亡率下降更明显,2组比较差异有统计学意义。结论辛伐他汀能改善慢性心衰患者的心功能、并使心衰住院率、死亡率有进一步下降。
Objective To observe the effect of simvastatin in the treatment of chronic heart failure. Methods A total of 74 patients with chronic heart failure were randomly divided into a simvastatin group and control group. The patients in the control group were treated by strengthening heart, benefiting urine and stretching vessel. The patients in the simvastatin group received simvastatin 20 mg every day for six months in addition to the therapy above mentioned in the control group. The indexes of left ventricular ejection fraction （LVEF）, left ventricular end-diastolic diameter （LVEDD）, and left ventricular end-systolic diameter were assayed in the two groups. Results There were significant differences in the ameliorative rates of symptorn; the rehospitalization rates, and the mortality between the two groups, P 〈0.05. Conclusions Sirnvastatin can improve heart function and downgrade the rehospitalization rate, and the mortality in the treatment of chronic heart failure.
出处
《中国校医》
2009年第6期672-673,共2页
Chinese Journal of School Doctor
