艾司西酞普兰与舍曲林治疗老年抑郁症疗效研究

Study of efficacy and safety of escitalopram and sertraline in the treatment of senile patients with depression

目的探讨艾司西酞普兰治疗老年抑郁症的疗效及安全性。方法68例老年抑郁症患者随机分为艾司西酞普兰组与舍曲林组,疗程4周。采用汉密尔顿抑郁量表(HAMD)评定疗效,不良反应量表(TESS)评定不良反应。结果艾司西酞普兰组显效率为82.4%,舍曲林组为79.4%,2组比较差异无显著性(P>0.05);艾司西酞普兰治疗组第1周末与舍曲林组HAMD评分比较有显著性差异(P<0.05)。艾司西酞普兰组不良反应发生率为38.2%,舍曲林组为44.1%,2组比较差异无显著性(P>0.05)。结论艾司西酞普兰与舍曲林治疗老年抑郁症疗效相当,艾司西酞普兰起效较舍曲林快。

Objective To study the efficacy and safety of escitalopram and sertraline in the treatment of senile depression. Methods Sixty-eight senile depression patients were randomly assigned to escitalopram group and sertraline group for 4 weeks. Clinical effectiveness were evaluated by HAMD, and adverse rections were assessed with TESS. Results The response rate were 82.4% in escitalopram group and 79.4% in sertraline group, with no singifieant difference between two groups （P 〉 0. 05 ）. At the end of 1 week treatment, there was significant difference in the scores of HAMD between two groups （ P 〈 0.05 ）. The adverse reactions were 38.2% in escitalopram group and 44. 1% in sertraline group, and there was no significant difference between two groups （ P 〉 0. 05 ）. Conclusions The efficacy of escitalopram in treating senile depression is similar to those of sertraline. Escitalopram takes effect more quickly than sertraline.