微孢子虫蛋白质及其与宿主互作的研究进展

Advances in the Research of Microsporidian Proteins and Their Interactions With Host Cells

微孢子虫(protozoan:microsporidia)是一类细胞内专性寄生的单细胞真核生物,可广泛寄生于几乎所有的动物。早期对微孢子虫的研究主要集中在对其种类的分离鉴定方面,随着大规模基因组测序的不断深入,极大地推动了微孢子虫的研究,尤其是微孢子虫具有独特的进化地位以及基因组、细胞器和物质能量代谢途径等简化进化的特点,使其成为当前研究的热点。综述了该领域近10年来在微孢子虫总蛋白组成成分分析、极丝蛋白和孢壁蛋白的分离鉴定,以及孢壁蛋白与宿主的相互作用等方面的研究进展,并简要概述了该领域研究存在的问题及后续研究课题。

Microsporidia are unicellular eukaryotes found in a wide variety of animal hosts as obligate intracellular parasites.Early studies on microsporidia had been mainly focused on isolation and identification of new species.As more and more genome sequencing projects were completed,the researches on microsporidia have been further promoted.Microsporidia became a hot research area because of its unique phylogenetic position and its largely reduced genome size and simplified cellular organelles and metabolic pathways.This article reviewed advances in the analyses of composition of total microsporidian proteins,identification of polar tube proteins and spore wall proteins,and interactions of spore wall proteins with host etc in the past ten years.Besides,existing problems and future perspectives in this area were briefly introduced.