黑木耳多糖抗血栓作用的研究

Study on the antithrombotic effect of polysaccharide of Auricularia auriculajudae

目的研究黑木耳多糖的抗血栓作用。方法黑木耳多糖系采用热水浸提法从东北黑木耳中提取。通过动物实验,分别测定了动脉血栓的血栓长度,血栓的干、湿重,特异性血栓形成时间(CTFT)和纤维蛋白血栓形成时间(TFT),血小板黏附率及血液黏度。结果黑木耳多糖灌胃给药后可明显延长CTFT和TFT,缩短体外血栓长度,并减轻其干、湿重,降低家兔血液黏度。对血小板黏附率无明显影响。结论黑木耳多糖具有较好的抗血栓作用。

Purpose To study on the antithrombotic effect of polysaccharide of Auricularia auriculajudae. Methods The method of hot water extraction for extracting polysaccharide from Auricularia auriculajudae was used. The antithrombotic effect was studied by animal experiments. The length and the weight of arterial thrombosis were determined. Characteristic thrombus formation time （CTFT）, and thrombus formation time （TFT）, the rate of platelet adhesion and the blood viscosity were determined also. Results As compared with the normal saline group, polysaecharide of Auricularia auriculajudae （ig） remarkedly prolonged CTFT and TFT. The length of thrombus was shortened. Thrombus wet weight, thrombus dry weight, and blood viscosity were decreased, yet had no significant influence on the rate of platelet adhesion. Conclusion Polysaecharides of Auricularia auriculajudae can significantly inhitit the formation of thrombus.