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抗肿瘤适体药物的研究进展 被引量：6

Development of anticancer aptamer drugs
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摘要 适体,也称为化学抗体,是近年来开发的颇具潜力的一类新型药物。适体由较短的DNA或RNA寡聚核酸组成,在体内形成专一和稳定的三维结构,可以与特定的靶蛋白结合。已批准上市的第1个适体药物为抗血管内皮生长因子的RNA分子Macugen,在临床上玻璃体内注射用于治疗年龄相关性黄斑变性。细胞和动物模型研究证明一些适体具有很好的抗癌作用,有几个适体药物已进入临床研究阶段。此文对近年来抗肿瘤适体药物的进展做一综述。
作者 刁勇 王立强 邱飞
机构地区 华侨大学分子药物学研究所 华侨大学分子药物教育部工程研究中心
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2009年第6期415-418,共4页 Chinese Journal of Biochemical Pharmaceutics
基金 国家高技术研究发展计划"863计划"资助项目(2008AA02Z135) 国家科技重大专项课题(2009ZX09103-643) 福建省科技计划重点项目(2009I0017)
关键词 适体 肿瘤 药物
分类号 R979.1 [医药卫生—药品]
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参考文献32

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  • 2吴海歌,姚子昂,白雪芳,杜昱光,林炳承.抑制肿瘤血管生成治疗策略研究进展[J].中国生化药物杂志,2007,28(2):130-132. 被引量：6
  • 3苏伟明,于立坚,马润娣,廖铭能,黄来珍,于廷曦.从赤组织中分离到的福安肽的抗肿瘤活性的初步研究[J].中国生化药物杂志,2008,29(1):9-11. 被引量：14
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二级参考文献55

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共引文献19

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二级引证文献21

中国生化药物杂志
2009年 第6期

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