期刊文献+

作用于电压门控Na^+通道的海洋生物毒素 被引量:1

Marine toxins that target voltage-gated sodiumchannels
下载PDF
导出
摘要 电压门控Na+通道是神经、肌肉和心脏产生和传递快速电信号的基础。在海洋生态系统中,有许多毒素通过与电压门控Na+通道相互作用,从而产生一系列的药理作用和毒理效应。此文综合介绍了作用于电压门控Na+通道的代表性海洋生物毒素。
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2009年第6期423-426,共4页 Chinese Journal of Biochemical Pharmaceutics
基金 全军"十一五"专项项目(06Z020) 上海市自然科学基金(06ZR14111)
  • 相关文献

参考文献18

  • 1William A C, Sandrine C, Vladimir Y Y, et al. Voltage-gated ion channels and gating modifier toxins[J] .Toxicon,2007,49(2):124-141.
  • 2Diss J K, Fraser S P, Djamgoz M B. Voltage-gated Na^+ channels : multiplicity of expression, plasticity, functional implications and pathophysiological aspects[ J]. Ear Biophys, 2004,33 (3) : 180-193.
  • 3Ekberg J, Craik D J,Adams D J. Conotoxin modulation of voltage-gated sodium channels[ J ]. Int J Biochem Cell Biol, 2008,40 ( 11 ) : 2363- 2368.
  • 4Ekberg J, Adams D J. Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain[J]. Int J Biochem Cell Biol, 2006,38 : 2005-2010.
  • 5Lee C H, Ruben P C. Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin [ J ]. Channels ( Austin), 2008,2 ( 6 ) : 407-412.
  • 6Lewis R J, Schroeder C I, Ekberg J, et al. Isolation and structure-activity of μ-conotoxin TⅢA, a potent inhibitor of tetrodotoxin-sensitive voltagegated sodium channels [ J ], Mol Pharrnacol, 2007,71 (3) : 676-685.
  • 7Terlau H, Olivera B M. Conus venoms:a rich source of novel ion channel-targeted peptides [ J ]. Physiol Rev, 2004,84 ( 1 ) : 41-68.
  • 8Cestele S, Catterall W A. Molecular mechanisms of neurotoxin action on voltage-gated sodium channels [ J ]. Biochimie, 2000, 82 ( 9-10 ) : 883- 892.
  • 9Zorn S, Leipold E, Hansel A, et al. The μO-Conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3[J]. FEBS Lett, 2006,580 : 1360-1364.
  • 10Daly N L, Ekberg J A, Thomas L, et al. Structures of μO-conotoxins from Conus marmoreus inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons [ J ]. J Biol Chem,2004,279(24) :25774-25782.

同被引文献10

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部