综合分析药物性肝损伤4076例

The statistic analysis of the 4 076 patients with drug induced liver injury

目的分析引起药物性肝损伤的原因、临床分型和预后。方法检索药物性肝损伤的相关文献并进行统计分析。结果本组资料显示药物性肝损伤以中年人居多,>60岁者占20.4%,病死率约3.1%;引起肝损伤的前三位药物分别为中草药、抗结核药及抗生素,损伤类型以肝细胞损伤型居多,占54.2%;我国南北方未见明显地域差异。结论必须对患者加强引导,要遵照医嘱用药;对医务人员加强培训,注意鉴别诊断,及时报告,妥善处置。

Objective To analysis the causes, clinical classification and prognosis of drug induced liver injury. Methods To analysis the retrieval documentary data of DILl using statistics method. Results In China, the middle age of the patients who had DILl with no difference in gender. 20.4% of them were older than 60 years. The first three causes of DILl were the use of Chinese herb, antituberculotic drugs, and antibiotics. There was no geographical difference. The most common hepatic injury type was hepatocyte injury, which account for 54.2%, and the fatality rate was about 3.1%. Conclusion It is necessary to educate and guide the patients to take medicine complying with doctor＇s advice. The medical staffs have to pay more attention to the diagnosis, report without delay, and deal with drug induced liver injury correctly.