化学诱变技术在微生物育种研究中的应用

Chemical mutation technique applied in microorganism breeding

化学诱变是一种传统而经典的微生物育种技术,不仅在高产工业菌株选育中得到广泛应用,而且近来还用于改造野生菌株代谢功能,以发现新产活性产物。本文简要综述常用化学诱变剂及其作用机制,以及化学诱变技术在微生物育种领域中的新近应用研究进展。

Chemical mutation technique is one of the conventional and classical mutation techniques for microorganism breeding, which is used not only widely in improving industrial strains but also recently in altering metabolic function of wild-type strains to obtain bioactive metabolites newly produced. This paper reviews chemical mutagenic agents in routine use, their action mechanisms, and recent development of chemical mutation technique applied in microorganism breeding.