健脾补肾法对拉米夫定治疗慢性乙型肝炎早期应答率的影响

The Effect of Early Response on Lamivudine Therapy in Patients with Chronical Hepatitis B and the Role of Jianpi Bushen Recipe in it

目的:观察中医健脾补肾法对拉米夫定治疗慢性乙型肝炎早期应答率的影响。方法:将160例患者随机分为对照组和观察组,每组80例。对照组予拉米夫定治疗,观察组在拉米夫定治疗基础上加中医健脾补肾方治疗,疗程均为24周。分别观察比较两组患者12周、24周后ALT、AST、HBV-DNA、乙肝三系的变化和CD4、CD4/CD8的比值。结果:治疗12周、24周后观察组患者肝功能ALT、AST的复常率和HBV-DNA的转阴率明显高于对照组(P<0.05);并且,治疗24周后观察组患者HBeAg血清转阴率和CD4、CD4/CD8比值明显高于对照组(P<0.05)。结论:健脾补肾法可以明显提高拉米夫定治疗慢性乙型肝炎的早期应答率,其机理之一与调节CD4、CD4/CD8水平等有关。

Objective ： To observe the effect of early response that jianpi bushen recipe to Chronical Hepatitis B Treated by Lamivudine. Methods： 160 patients were divided into two groups at random, eighty patients were only given to Lamivudine. eighty patients were given to Lamivudine and jianpi bushen recipe. The treatment lasted for 24 weeks in both groups. Liver function HBeAg HBV - DNA CD4 CD4/CD8 rate were surveyed at 12weeks and 24weeks in both groups. Results ： After 12 weeks and 24 weeks , the recovery rate of liver function and HBV - DNA of observation group were higher than those of control group（ P 〈 0.05 ）. After 24 weeks, HBeAg divert rate CD4 CD4/CD8 of observation group were high- er than those of control group （P 〈0. 05）. Conclusion： Jianpi bushen recipe can significantly improve the early response effect of chronical hepatitis B treated by Lamivudine ,one of which is related to the level of CD4 CD4/CD8 ratio.