体检人群成人血清胆红素水平临床研究

Serum bilirubin level in healthy population

目的观察本院体检人群血清胆红素水平。方法2008年在本院参加体检的企事业单位人员共计14315例，排除肝胆疾病和溶血性疾病和各种原因所致的贫血性疾病的人群，排除黄疸、脂血、溶血标本。共12387例入选，中位年龄53岁。测定血清总胆红素（TBIL）和直接胆红素（DBIL），按照不同年龄、性别进行分组统计，分析检测结果，并与现用的参考区间进行比较，观察胆红素水平。结果不同性别人群胆红素检出结果无统计学差异，中老年组TBIL、DBIL检测值较青年组高。北京地区体检人群血清TBIL水平比现用的参考区间明显上升（P〈0．05）。青年组血清TBIL水平（5．7～29．5）μmol／L，DBIL水平（0．9—5．5）μmol／L，中老年组TBIL水平（6．0～30．3）μmol／L，DBIL水平（0．9—5．7）μmol／L。结论北京地区体检人群TBIL水平与现用参考区间相比上限明显增高。

Objective To investigate the serum level of bilirubin in healthy populations. Methods A total of 14 315 individuals took physical examination in our hospital in 2008. When liver and gallbladder diseases,hemolytic diseases, anemia, jaundice, lipemia, and hemolytic samples were excluded, the rest of 12 387 subjects （median age ,53 years） were assigned to the different age or gender groups. The high-level automatic biochemical analyzer was used for serum total bilirubin （TBIL） and direct bilirubin （DBIL）. Results There was no difference in serum bilirubin between men and women. TBIL of individuals living in Beijing was higher than reference （ P 〈 0. 05 ）. In young group, serum TBIL level was 5.7 to 29. 5 μmol/L and DBIL was 0. 9 to 5.5 μmol/L In elderly group, serum level of TBIL was 6. 0 to 30. 3 μmol/L and DBIL was 0. 9 to 5.7 μmol/L. Conclusion Serum TBIL level of Beijing residents may higher than the upper limit of recommended reference.