摘要
目的探讨CK19和Galectin-3在鉴别甲状腺良恶性肿瘤中的应用价值。方法应用免疫组织化学EnVision法检测CK19和Galectin-3蛋白在甲状腺乳头状癌、甲状腺腺瘤、结节性甲状腺肿和桥本甲状腺炎中的表达。结果CK19和Galectin-3蛋白在甲状腺乳头状癌、甲状腺腺瘤、结节性甲状腺肿和桥本甲状腺炎中的阳性表达率分别为97.9%、6.7%、5.6%、46.7%和100.0%、26.7%、16.7%和93.3%。结论CK19和Galectin-3蛋白在甲状腺乳头状癌与甲状腺腺瘤、结节性甲状腺肿鉴别诊断中具有较高的应用价值,而对甲状腺乳头状癌与桥本甲状腺炎的鉴别诊断受到限制。
t Objective To study the diagnostic value of combination detection with galeetin- 3 and CK19 in benign or malignant thyroid tumor. Methods Immunohistochemistry （envision method） was employed to detect the expression of galectin- 3 and CK19 protein in benign or malignant thyroid tumor. Results The positive rate of galectin- 3 and CK19 protein in thyroid papillary carcinoma, thyroid follicular adenoma, nodular goiter and Hashimoto＇s thyroiditis were 97.9%, 6.7%, 5.6%, 46.7% and 100%, 26.7%, 16.7%, 93.3%, respectively. Conclusion CK19 and galectin-3 are important markers in distinguishing thyroid papillary carcinoma with thyroid follicular adenoma, nodular goiter, but restricted in Hashimoto＇s thyroiditis.
出处
《中国煤炭工业医学杂志》
2009年第12期1847-1848,共2页
Chinese Journal of Coal Industry Medicine
