摘要
本文对13只健康AA鸡单次内服喹乙醇中毒剂量(120mg/kg)作了毒物动力学分析。用乙腈—乙酸乙酯混合溶剂提取血浆中的喹乙醇,反相高效液相色谱法(HPLC法)测定浓度。喹乙醇内服给药的药时数据适合一级吸收二室开放模型。毒物动力学主要参数为:t1/2Ka0.63±0.26h,t1/2α1.12±0.34h,t1/2β7.26±3.02h,Ke0.59±0.15h-1,Tmax1.19±0.31h,Cmax71.40±12.81μg/ml,AUC258.12±36.11mg/L.h。本试验表明,内服中毒剂量的喹乙醇在AA鸡体内的吸收、分布均很迅速,但消除缓慢;给药后24h,血药浓度均高于0.
The toxicokinetic characteristics of olaquindox were investigated after administering a single oral toxic dose (120 mg/kg b w ) to 13 healthy AA broilers Olaquindox in plasma was extracted with acetonitrile ethyl acetate (3:2,v/v) and determined by HPLC The drug concentration vs time was fitted to a two compartment open model with first order absorption rate The main toxicokinetic parameters were as follows:t 1/2Kα 0 63±0 26 h,t 1/2α 1 12±0 34 h,t 1/2β 7 26±3 02 h,ke 0 59±0 15h -1 ,T max 1 19±0 31 h,C max 71 40±12 81 μg/ml,AUC 258 12±36 11 mg/L h The results suggested that the absorption and distribution processes of olaquindox were rapid while the elimination was very slow with a single oral toxic dose of 120 mg/kg
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
1998年第5期438-442,共5页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
关键词
喹乙醇
鸡
毒物动力学
生化毒性
病理学
Olaquindox
Broilers
Toxicokinetics
High performance liquid chromatogram