喹乙醇在鸡体内的毒物动力学及其生化毒性和病理学研究

STUDIES ON TOXICOKINETICS OF OLAQUINDOX IN BROLIERS

本文对１３只健康ＡＡ鸡单次内服喹乙醇中毒剂量（１２０ｍｇ／ｋｇ）作了毒物动力学分析。用乙腈—乙酸乙酯混合溶剂提取血浆中的喹乙醇，反相高效液相色谱法（ＨＰＬＣ法）测定浓度。喹乙醇内服给药的药时数据适合一级吸收二室开放模型。毒物动力学主要参数为：ｔ１／２Ｋａ０．６３±０．２６ｈ，ｔ１／２α１．１２±０．３４ｈ，ｔ１／２β７．２６±３．０２ｈ，Ｋｅ０．５９±０．１５ｈ－１，Ｔｍａｘ１．１９±０．３１ｈ，Ｃｍａｘ７１．４０±１２．８１μｇ／ｍｌ，ＡＵＣ２５８．１２±３６．１１ｍｇ／Ｌ．ｈ。本试验表明，内服中毒剂量的喹乙醇在ＡＡ鸡体内的吸收、分布均很迅速，但消除缓慢；给药后２４ｈ，血药浓度均高于０．

The toxicokinetic characteristics of olaquindox were investigated after administering a single oral toxic dose (120 mg/kg b w ) to 13 healthy AA broilers Olaquindox in plasma was extracted with acetonitrile ethyl acetate (3:2,v/v) and determined by HPLC The drug concentration vs time was fitted to a two compartment open model with first order absorption rate The main toxicokinetic parameters were as follows:t 1/2Kα 0 63±0 26 h,t 1/2α 1 12±0 34 h,t 1/2β 7 26±3 02 h,ke 0 59±0 15h -1 ,T max 1 19±0 31 h,C max 71 40±12 81 μg/ml,AUC 258 12±36 11 mg/L h The results suggested that the absorption and distribution processes of olaquindox were rapid while the elimination was very slow with a single oral toxic dose of 120 mg/kg