紫杉醇联合化疗方案治疗晚期胃癌的疗效观察被引量：4

下载PDF

导出

摘要目的评价含紫杉醇(Taxol)化疗方案治疗晚期胃癌的临床疗效和毒副反应。方法用含紫杉醇联合化疗方案治疗晚期胃癌患者20例,包括Taxol+5-FU12例,Taxol+DDP8例。应用后按WHO标准评价疗效和毒副反应。结果无完全缓解(CR)患者;部分缓解(PR)7例,占35%;稳定(SD)9例,占45%;进展(PD)4例,占20%;总有效率(CR+PR)为35%,临床受益率为75%。主要毒性反应为白细胞减少20例(100%)、血红蛋白降低17例(85%)、脱发18例(90%)、肌肉关节痛14例(70%)等,无治疗相关性死亡。结论以紫杉醇为主的联合化疗方案治疗晚期胃癌有较好的疗效,毒性反应轻可耐受,值得在临床上推广。

作者姜明敏

机构地区辽宁省兴城市沈阳军区兴城疗养院疗养三科

出处《中国医药指南》 2009年第24期40-42,共3页 Guide of China Medicine

关键词紫杉醇药物治疗晚期胃癌

分类号 R735.2 [医药卫生—肿瘤]

引文网络
相关文献

参考文献6

1Gadgeel SM, Shields AF, Heilbrum LK, et al. Phase Ⅱ study of paclitaxel and carboplatin in patients with advanced gastric cancer[J]. Am J Clin Oncol, 2003,26(1):37-38.
2Sasaki T, Maeda Y, Kobayashi T, et al. Standard chemotherapy for gastrointestinal malignancies based on evidence[J]. Jpn J Cancer Chemother, 2000, 27(20): 166-176.
3Tahara M, Ohtsu A. Latest progress on chemotherapy for advanced gastric cancer[J]. Jpn J Gan To Kagaku Ryoho, 2000, 27(13):2048-2058.
4Ohtsu A,Boku N,Tamura F,et al. An early phase Ⅱ study of a 3? hour infusion of paclitaxel for advancsd gastric cancer[J].Am J Clin Oncol, 1998,21(4):416-419.
5Soto Parra H, Cavina R,Latteri F, et al. Three-week versus four week schedule of cisplatin and gemcitabine: Results of a randomized phase Ⅱ sludy[J].AnnOncol,2003,13:1080-1082.
6冯继锋,陆建伟,孙小峰.氟尿嘧啶/亚叶酸钙+紫杉醇联合化疗双周方案治疗晚期胃癌[J].癌症,2004,23(12):1704-1706. 被引量：14

二级参考文献7

1Ohtsu A,Boku N,Tamura K,et al. An early phaseⅡ study of a 3-hour infusion of paclitaxel for advanced gastric cancer [J]. Am J Clin Oncol,1998,21(4):416- 419.
2Murad AM,Petroianu A,Guimaraes RC,et al. 5-fluorouracil in the treatment of advanced gastric cancer:a norel,safe,and effective regimen [J]. Am J Clin Oncol,1999,22(6):580- 586.
3周际昌.实用肿瘤内科学 [M].北京:人民卫生出版社, 1998:22- 34.
4Tahara M, Ohtsu A. Latest progress on chemotherapy for advanced gastric cancer [J]. Jpn J Gan To Kagaku Ryoho, 2000, 27(13):2048- 2058.
5Louvet C,de Gramont A,Demuynck B,et al. Short report,high-dose folinicacid,5-fluorouracil bolus and continuous infusion in poor-prognosis patients with advanced measurable gastric cancer [J]. Ann Oncol,1991, 2:229- 239.
6亓玉琴,朱菊人,刘吉勇,许洪伟,姜军梅,王春霞.紫杉醇诱导胃癌细胞凋亡及对端粒酶活性调节的关系[J].临床消化病杂志,2001,13(6):243-246. 被引量：12
7周宁宁,周中梅,刘茂珍,李宇红,徐瑞华,滕小玉,向晓娟,田维华,刘冬耕,胡丕丽,张蓓,丘惠娟,钱穗毅,何友兼.紫杉醇和5-氟尿嘧啶/醛氢叶酸双周疗法治疗晚期胃癌的初步报告[J].癌症,2003,22(8):867-869. 被引量：26