剖宫产用高浓度（0．75％）布比卡因腰-硬联合麻醉可致脊神经损害

CSEA with High Concentration （0.75%） Bupivacain for Cesarean Section May Injury to the Spinal Neurons

目的：讨论有关剖宫产术腰-硬联合麻醉0．75％布比卡因致脊神经毒性损害的可能性原因分析。方法：通过8例剖宫产腰-硬联合麻醉临床医疗事件调查．发现2例为短暂性神经症状群（TNS）．经治疗后2周内恢复；6例为双下肢功能障碍（瘫痪）．观察了18个月，部分病例恢复。结合有关文献复习．对腰-硬联合麻醉用高浓度布比卡因致脊神经毒性损害的可能性与相关因素作充分的论证。结论：剖宫产术腰-硬联合麻醉后发生严重脊神经损害与高浓度（0．75％）布比卡因的神经毒性明显有关，值得重视。

Objective： The aim of this paper would be discussed to high concentration （0.75%） bupivacain inducing the possibility of spinal neurons injury during cesarean section. Methods： Though the studies of 8 cases cesarean section woman, They were suffered from medical event after CSEA. 2 cases with Transient Neurologic Syndrome, they has had totally recover from the injury. However the 6 cases occurred with paralysis in the lower part of body, after treatment their lower legs function were restoration in only some cases. Conclusion： The spinal neurological injury after cesarean section by CSEA were significant related to high concentration （0.75%） of bupivacaine. It would be worth paying more attention.