高胆固醇血症对家兔Oddi括约肌功能的影响

Motor function changes of sphincter of Oddi in rabbits with hypercholestercmia

目的探讨高胆固醇血症对家兔Oddi括约肌运动功能的影响。方法将32只家兔分为对照组和高胆固醇血症4、6、10周组，每组8只，进行Oddi括约肌压力及肌电的测定。采用t检验对结果进行分析。结果高胆固醇血症10周组与对照组比较，血清总胆固醇和低密度脂蛋白含量较高（t=9．63，11．38，P〈0.05）；Oddi括约肌基础压、峰压、振幅升高（t=5．23，6．34，3．24，P〈0．05）；肌电活动由原来的锋电位变为肌电簇，肌电簇持续时间延长，每簇放电率降低（t=13．68，10．18，P〈0．05）。结论家兔发生高胆固醇血症时，胆汁成分发生改变，提高了Oddi括约肌的张力，同时加快Oddi括约肌蠕动，加速胆汁的排泄。

Objective To investigate the effects of hypercholesteremia on the motor function of sphincter of Oddi （SO）. Methods Thirty-two rabbits were divided into control group and experimental groups. In the control group, the rabbits were fed with normal diet. In the experimental groups, the rabbits were fed with normal diet ＋ cholesterol for 4, 6 and 10 weeks. Myoelectric activity and pressures of SO were detected. All data were analyzed by t test. Results The serum total cholesterol and low density lipoprotein cholesterol were at a high level in rabbits which were fed with normal diet ＋ cholesterol for 10 weeks （ t = 9.63, 11.38, P 〈 0.05） ; basal pressure, pike pressure and amplitude of SO were significantly elevated （t = 5.23, 6. 34, 3.24, P 〈 0.05） ; the spike potential of SO changed to myoelectronie activity, with prolonged time period of myoeleetronie activity, while the discharge rate was decreased （t = 13.68, 10. 18, P 〈 0.05）. Conclusion Hypereholesteremia may change the motor function of SO and enhance its peristalsis to speed up the excretion of bile.