环戊通对成年豚鼠眼屈光度检测结果的影响

The effect of cyclopentolate cycloplegic on the refraction measurement in adult guinea pigs

目的研究麻痹睫状肌对豚鼠眼屈光度检测的影响。设计实验研究。研究对象10周龄英国种豚鼠12只(24眼)。方法带状光检影法(SR)在应用1%环戊通(cyclopentolate cycloplegic)散瞳前、后各检测双眼屈光度3次,间隔时间1小时。主要指标豚鼠眼球镜、柱镜和等效球镜度数。结果豚鼠眼散瞳前后平均等效球镜值分别为(1.92±0.79)D和(2.08±0.79)D,配对t检验散瞳前后球镜、柱镜和等效球镜测量值的差异无统计学意义。方差分析散瞳和不同测量时间两个分析因素对球镜、柱镜和等效球镜的测量结果的影响均无统计学意义。结论1%环戊通对成年豚鼠眼屈光度检测结果影响有限,成年豚鼠可以在自然生理状态下进行屈光度检测。

Objective To investigate the effect of cyclopentolate cycloplegic on the refraction measurement in adult guinea pigs. Design Experimental study. Participants 24 eyes of 12 （10 weeks） adult guinea pigs. Methods 12 animals were randomly examined thrice by streak retinoscopy pre and post mydriasis. 1% cyclopentolate hydroehloride was topically administrated to the eye every five minutes for three times. Main Outcome Measures The eye refraction of guinea pigs included the scope, cylinder and the equivalent power. Results The average refraction of guinea pigs in pre-mydriasis and post-mydriasis were 1.92±0.79 D and 2.08±0.79 D respectively. The average refraction that included the scope, cylinder and the equivalent power all showed no significant difference between pre and post mydriasis. The effect of mydriasis and measure time points on the refraction that included the scope, cylinder and the equivalent scope showed no significant difference either. Conclusions The effect of 1% cyelopentolate cyeloplegic on adult guinea pigs in refraction is limited. The refraction of adult guinea pig can be measured naturally without cyclopentolate cycloplegie administrated.