静脉化疗联合高压氧治疗转移性胃癌的临床研究

Clinical research on metastatic gastric cancer treated with hyperbaric oxygen combined with chemotherapy

目的研究高压氧联合化疗治疗转移性胃癌的临床疗效、毒副反应及其可能机制。方法采用随机分组为对照组、治疗组分别应用FLP化疗及高压氧联合FLP治疗转移性胃癌共60例,并进行临床疗效、临床不良反应症状观察和实验室检查。结果治疗组有效率为46.7%,对照组有效率为43.3%,两者比较差异无统计学意义(P>0.05)。治疗组TTP、OS恶心呕吐、乏力、便秘、骨髓抑制发生率比较差异均有统计学意义(P<0.05)。结论高压氧联合化疗可延长患者病灶进展时间及生存期,能减轻部分化疗毒副反应,提高患者化疗耐受性。

Objective To study clinical efficacy,adverse effects and the mechanisms of hyperbaric oxygen combined with chemotherapy in the treatment of metastatic gastric cancer.Methods Sixty metastatic gastric cancer patients were randomly divided into a treatment group and a control group.Then the patients were treated respectively with hyperbaric oxygen combined with FLP therapy and FLP chemotherapy alone to observe the curative effect,the clinical adverse effect and the laboratory examination.Results The effective power of hyperbaric oxygen combined with chemotherapy was 46.7% in the treatment group and 43.3% in the control group.There was no significant difference between the two groups （P0.05）.There were significant difference （P0.05） in time to progressive,overall survival and incidence of nausea and vomiting,debilitation,constipation and myelosuppression between the two groups.Conclusion Hyperbaric oxygen combined chemotherapy in the treatment of metastatic gastric cancer is efficacious and well tolerable;time for progressive and overall survival can be prolonged.