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MMP-2/TIMP-2系统与原发性开角型青光眼的相关性分析

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摘要 目的探讨基质金属蛋白酶-2/金属蛋白酶组织抑制因子-2(MMP-2/TIMP-2)系统在原发性开角型青光眼中的可能发病机制。方法正常人尸眼20只,中期原发性开角型青光眼患者20只眼,晚期原发性开角型青光眼22只眼,均行常规小梁切除术,采用RT-PCR法检测小梁网组织中MMP-2 mRNA和TIMP-2 mRNA的表达。结果正常人和中、晚期原发性开角型青光眼小梁网均有MMP-2 mRNA和TIMP-2 mRNA的表达;MMP-2 mRNA在正常人小梁网呈高表达,在原发性开角型青光眼中表达明显下调,且随病程发展其表达逐步降低;TIMP-2 mRNA在正常人小梁网呈低表达,在原发性开角型青光眼中表达明显上调,且随病程发展其表达逐步升高;原发性开角型青光眼小梁网MMP-2 mRNA/TIMP-2 mRNA比值明显低于正常人,且随病程发展比值逐步减小。结论小梁网细胞外基质TIMP对MMP的异常抑制,造成MMP-2/TIMP-2系统的失衡,可能是原发性开角型青光眼的发病机制之一。
作者 梁好 宋明胜
机构地区 中南大学湘雅二医院检验科 中南大学湘雅三医院检验科
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2009年第6期777-778,780,共3页 Journal of Xi’an Jiaotong University（Medical Sciences）
关键词 原发性开角型青光眼 小梁网 细胞外基质 基质金属蛋白酶-2 基质金属蛋白酶抑制因子-2
分类号 R775.2 [医药卫生—眼科]
  • 相关文献

参考文献10

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二级参考文献23

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西安交通大学学报（医学版）
2009年 第6期

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