CD117、CD34、Ki-67在胃肠道间质瘤中的表达及意义

Expression of Ki-67 and cluster of differentiation 34 and 117 in gastrointestinal stromal tumors

目的:探讨胃肠道间质瘤的临床病理和免疫组织化学特征.方法:观察53例间质瘤的病理形态特征,并用免疫组织化学EnVison法检测CD117、CD34、SMA、S-100及Ki-67的表达.结果:CD117、CD34、SMA、S-100及Ki-67的阳性表达率分别为:88.7%(47/53)、81.1%(43/53)、50.9%(27/53)、18.9%(10/53)及67.9%(36/53).结论:联合检测CD117与CD34可以提高间质瘤的诊断准确性,Ki-67阳性表达与肿瘤大小和危险程度相关,可作为间质瘤的预后指标.

AIM： To investigate the clinicopathologic and immunohistochemical features of gastrointestinal stromal tumors （GISTs）. METHODS： A total of 53 cases of GISTs were included in the study. The expression of cluster of differentiation 117 （CD117）, cluster of differentiation 34 （CD34）, smooth muscle actin （SMA）, S-100 protein and Ki-67 in GIST specimens was detected by immunohistochemistry. The clinicopathologic features of GISTs were also analyzed. RESULTS： Of 53 GIST specimens, 47 were positive for CDl17 （47/53, 88.7%）, 43 positive for CD34 （43/53, 81.1%）, 27 positive for SMA （27/53, 50.9%）, 10 positive for S-100 （10/53, 18.9%）, and 36 positive for Ki-67 （36/53, 67.9%）. CONCLUSION： Combined detection of CDl17 and CD34 can improve the diagnostic accuracy of GISTs. The expression of Ki-67 can be used as a prognostic parameter for GISTs as it is correlated with tumor size and risk.