原发性高血压患者血浆一氧化碳和硫化氢水平变化的临床意义

Plasma Carbon Monoxide and Hydrogen Sulfide in Patients with Essential Hypertensive Patients

目的探讨气体信号分子一氧化碳及硫化氢在原发性高血压患者中的意义。方法选择原发性高血压患者85例,按照血压水平分1、2、3级高血压组,均无服用降压药物、调脂药物或已停服降压药1月以上,排除继发性高血压、糖尿病、冠心病、高脂血症等。同时选取正常对照组27例。检测入选者的血浆一氧化碳及硫化氢浓度。结果1级高血压患者血浆一氧化碳含量与对照组比较[(18.6±1.9)比(21.1±2.4)mmol/L,P>0.05],差异无统计学意义;2、3级高血压患者血浆一氧化碳含量较对照组降低[(15.4±1.4)、(12.5±1.7)比(21.1±2.4)mmol/L,P<0.05];1、2、3级高血压病人血浆硫化氢含量较对照组降低[(43.7±1.4)、(37.6±1.8)、(26.7±1.3)比(51.4±1.4)mmol/L,P<0.05];随血压水平升高,血浆一氧化碳及硫化氢含量降低,原发性高血压患者平均动脉压与血浆一氧化碳和与硫化氢呈负相关(r=-0.542、r=-0.682,均P<0.05),血浆一氧化碳与硫化氢呈正相关(r=0.627,P<0.05)。结论一氧化碳和硫化氢均可能在血压调节中起作用。

Objective To study the implication of carbon monoxide （CO） and hydrogen sulfide （H2S） in essential hypertensive patients. Methods A total of 85 essential hypertensive patients were enrolled in this study and categorized into grade 1, 2 and 3 according to hypertension grading criteria. Patients have been discontinued antihypertensive and antihydealipidense medicines for〉 1 month and patients complicated with diabetes mellitus, coronary heart disease, hyperlipemia, or suspected having secondary hypertension were excluded, etc. Twenty-seven healthy served as controls. Plasma CO content and H2S concentration were determined. Results Compared with controls, No marked difference of plasma CO levels were found between patients with hypertension grade 1 and controls [（18.6±1.9）vs（21.1±2.4）mmol/L, P〉0.05], but patients with grade 2 and 3 had significantly lower Plasma CO levels, [（15.4±1.4）, （12. 5±1.7）vs（21.1±2. 4）mmol/L, P〈0. 05]; Plasma H2S level in all 3 grades of hypertensive patients are lower than that of controls[（43.7±1.4） ,（37.6±1.8） ,（26.7±1.3） vs （51.4±1.4）mmol/L, P〈0.05]; Plasma CO and H2S are negatively correlated with BP levels（r=-0. 542, r=-0. 682, respectively P〈0.05）, and decreased with the increasing of blood pressure. Plasma H2S are positively related with pleasure CO（r=0. 627, P〈0.05）. Conclusion As a signaling gasotransmitters, plasma CO and H2 S might play roles in the pathogenesis and development of hypertension.