期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TACE-TGF-α相互作用参与胚泡着床的机制研究 被引量：2

The regulation investigation of the interaction between TACE and TGF-α
下载PDF
导出
摘要 目的:探讨胚泡着床过程中转化生长因子α(Transforming growth factor-α,TGF-α)对肿瘤坏死因子-α转化酶(Tumor necrosis factor-converting enzyme,TACE/ADAM17)的反馈调控机制。方法:用逆转录聚合酶链反应(Reverse transcription polymerase chain reaction,RT-PCR)和免疫组化的方法分别检测实验组(注射TGF-α抗体)和对照组(注射小鼠血清)后子宫内膜TACE mRNA和蛋白的表达。结果:对照组TACE mRNA和蛋白明显高于实验组。结论:在胚胎着床过程中,TGF-α能反馈调控TACE在子宫内膜的表达,TACE-TGF-α-EGFR途径可能是胚胎着床的调控机制之一。 Objective：To investigate the feedback regulation of transforming growth factor α （TGF-α） to tumor necrosis factor-α converting enzyme. Methods： Reverse transcription polymerase chain reaction （RT-PCR） and immunochemistry were applied to detect TACE mRNA and protein in mice endometria of experiment group （TGF-α antibody was injected） and control group （saline was injected）. Results ： The expressions of TACE mRNA and protein in control group were higher than in experiment group. Conclusion： TGF-α could feedback on TACE expression in mice endometria and TACE-TGF-α-EGFR might one of the regulations during blastocyst implantation.
作者 杨环 朱兴春 杨戎 张文文 刘帅
机构地区 重庆医科大学公共卫生学院生殖生理教研室 川北医学院检验科
出处 《重庆医科大学学报》 CAS CSCD 北大核心 2009年第11期1466-1469,共4页 Journal of Chongqing Medical University
基金 重庆市科委自然科学基金项目(CSTC 2007BB5273)
关键词 胚胎着床 肿瘤坏死因子-α转化酶 转化生长因子Α 子宫内膜 免疫组化 逆转录聚合酶链反应 Blastocyst implantation Tumor necrosis factor alpha converting enzyme（TACE ） Transforming growth factor-α （TGF-α ） Endometria Immunochemistry RT-PCR
分类号 R394 [医药卫生—医学遗传学]
  • 相关文献

参考文献11

  • 1Moss M L, Jin S L, Milla M E, et al. cloning of a disintegrin metalloproteinase that processes precursor tumour necrosis factor-alpha[J]. Nature, 1997,385:733-736.
  • 2Kumar V, Bustin S A, M ckay L A. Transforming growth factor alpha [J]. Cell Bio Int, 1995,19 (5) : 373-388.
  • 3Tamada H, Das S K, Dey S K, et al. Cell2type2specific expression of transforming growth factor alpha in the mouse uterus during the peri-imp lantation period [J].Bio Rep rod, 1991,45 (2):365-372.
  • 4Bonvissuto A C, L ala P K, Dennedy T G,et al. Induction of transforming growth factor alpha gene expression inrat deeiduas is independent of the concep tus [J]. Bio Reprod, 1992,46 (4) : 607-616.
  • 5Borrell-Pags M, Rojo F, Albanell J, et al. TACE is required for the activation of the EGFR by TGF- α in tumors[J]. EMBO J, 2003,22( 12 ) :1114-1124.
  • 6Daniel D, Indrani B,Sudhandsu K,et al.Embryo Implantation[J]. Developmental Biology, 2000,223 (2) :217-237.
  • 7W ells A. EGF receptor[J]. Int J Biochem Cell Bio, 1999,31 (6) : 637-643.
  • 8Paria B C, Das S K, Dey S K, et al.Distribution of transforming growth factor precursors in the mouete Tus during the perlimplantation period and after steroid hormone treatments[J]. Bio Reprod, 1994,50(3 ) :481-491.
  • 9Bush M R, Mele J M, Walmer D K, et al.Evidenee of Juxtaerine signaling for transforming growth factor alpha in human endometrium[J].Bio Reprod, 1998,59 (6) : 1522-1529.
  • 10Hart S,Fischer O M, Prenzel N,et al. GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways [J]. Biol Chem, 2005,386 (9) : 845-855.

同被引文献15

  • 1Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: nmhidomain proteins with multiple functions [J]. Genes Dev, 2003, 17(1): 7-30. DOl:10,1101/gad. 1039703.
  • 2Blobel CP, Wolfsberg TG, Turck CW, et al. A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion[J]. Nature, 1992, 356(6366): 24-8-252. DOI : |0. 1038/356248a0.
  • 3Rooke J, Pan D, Xu T, et al. KUZ, a conserved metalloprotease -disintegrin protein with two roles in Drosophila neurogenesis [ J ]. Science, 1996, 273 (5279) : 1227- 1231.
  • 4Black RA, Raueh CT, Kozlosky C J, et al. A metalloproteinasedisintegrin that releases tumour - necrosis factor - alpha from cells[ J ]. Nature, 1997, 385 (6618) : 729- 733. DOI: 10. 1038/385729a0.
  • 5Thathiah A, Blobel CP, Carson DD. Tumor necrosis factor - alpha converting enzyme/ADAM 17 mediates MUC1 shedding [J]. J Biol Chem, 2003, 278 (5): 3386- 3394. DOI:10. 1074/jhe. M208326200.
  • 6Carson DD, Bagchi I, Dey SK, et al. Embryo implantation[J]. Dev Biol, 2000, 223 ( 2 ) : 217-237. DOI : 10. 1006/dbio. 2000. 9767.
  • 7Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis[ J]. Development, 1988, 102 (4) : 639-655.
  • 8Liu N, Zhang J, Ji C. The emerging roles of Notch signaling in leukemia and stem cells[J]. Biomark Res, 2013, 1 ( 1 ) : 23. DOI : 10,1186/2050-7771 - 1 - 23.
  • 9Bol6s V, Grego - Bessa J, de la Pompa JL. Notch signaling in development and cancer[ J]. Endocr Rev, 2007, 28 (3) : 339- 363. DOI:10. 1210/er. 2006 -0046.
  • 10De Faleo M, Cobellis L, Giraldi D, et al. Expression and distribution of notch protein members in human placenta throughout pregnancy [ J ]. Placenta, 2007, 28 ( 2 - 3 ) : 118- 126. DOI : 10. 1016/j. placenta. 2006.03. 010.

引证文献2

重庆医科大学学报
2009年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部