川芎嗪注射液对TIA患者血小板活化功能及预后的影响

Effect of Ligustrazine Hydrochloride Injection on Platelet Activation and Prognosis in Transient Ischemic Attack

目的探讨川芎嗪注射液对短暂脑缺血发作患者血小板活化功能及预后的影响及其机制。方法62例短暂脑缺血发作患者,随机分为治疗组及对照组,两组患者给予相同的扩血管、抗凝治疗,治疗组另给予川芎嗪干预治疗,共28d,采用酶联免疫吸附法观察两组患者血清凝血酶原时间(PT)、部分活化凝血酶原时间(APTT)、凝血酶原时间(TT)、纤维蛋白原(FIB)水平变化,采用流式细胞仪检测血清血小板第四因子(PF4)、可溶性P选择素(CD62P)、纤维蛋白原受体(PAC-I)表达变化,并比较两组患者的预后情况。结果治疗组同对照组相比,PT、APTT、TT延长,PF4及CD62P表达水平降低,FIB及PAC-1表达无差异,治疗组发作率及进展为脑梗死率少于对照组。结论川芎嗪注射液能够改善TIA患者血小板活化状态,减少再发作,改善TIA患者预后。

Objective To investigate effect of ligustrazine hydrochloride injection on platelet activation and prognosis in paitients with transient ischemic attack（TIA）. Methods Sixty-two patients with TIA were randomly divided into treatment group and control group. Both groups received the same vasodilative,anticoagulation therapy and lignstrazine hydrochloride injection was added to the treatment group for 28 days. Prothrombin time （PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）and fibrinogen in serum were observed by using enzyme linked immunosorbentassay, and the expression of platelet factor 4（PF4）, CD62 P and PAC-I were detected with flow cytometer. The prognosis of the two groups was compared. Results In comparison with control group,the PT,AP/T and TT were delayed in the treatment group,the expression of PF4 and the CD62P were decreased,the FIB and PAC-1 were identical,and the attack rate and cerebral infarction were lower in the treatment group than those in the control group. Conclusion Ligustrazine hydrochloride injection can decrease platelet activation in paitients with TIA and infarction re-attack, and improved the prognosis in TIA.