近红外线测定在缺血性卒中中的应用

Near-Infared Spectroscopy Apply to Cerebral Ischemia

近年来,缺血性卒中的发病呈上升趋势,早期诊断、及时治疗是减少其病死率及致残率的关键。近红外线光谱(near-nfrared spectroscopy,NIRS)是利用近红外光在人脑组织的传导和吸收来获得血红蛋白和氧合血红蛋白等含量变动的信息,具有良好的时间和一定的空间分辨率、便携以及持续的床边监测,已成为临床脑生理学检测的有力手段,可无创地实时监测大脑局部氧饱和度和血流动力学。尽管NIRS有一定的局限性,但正逐渐被广泛的应用到缺血性卒中的诊疗、病中监测、结局预测、康复评定以及高原缺氧缺血性脑功能障碍检测中。NIRS安全无创、设备简单、操作方便,其临床应用前景广阔。

In recent years, the incidence of cerebral ischemia is increasing. It is of great importance to make an early diagnosis and timely treatment to reduce the morbility and mortality. Generally, the cerebral ischemia can be cured if the disease could be diagnosed within half an hour. Therefore many scholars thought that forecast and prevention were more important than treatment. Near infrared spectroscopy（NIRS） can be used for non-invasive assessment of the brain function through an skull in human subjects by detecting changes in blood hemoglobin concentrations associated with neural activity and monitoring oxygen saturation degree and blood stream dynamics of partial cerebrum in real time. NIRS have many excellent characteristics such as time and space resolution, portable and bedside monitoring. NRIS has become a useful method for clinical brain physiology examination. It has been widely used for diagnosis, treatment, monitoring, and rehabilitation by monitoring the values of Hb, OxyHb and cerebral blood flow despite certain limitations. NIRS is safe, non-invasively and easy to operation. NIRS will be widely used in clinical practice.