新疆维吾尔族JC病毒基因型的分布状况研究

Distribution of the JC Virus Genotypes of the Uighur People in the Xinjiang

文章对维吾尔族的JC病毒IG区域基因型的地理分布状况进行了对比研究。从103个40岁以上的男性尿样提供者中分离出了JC病毒,并且对它们进行了DNA提取,对JC病毒IG区域进行了PCR扩增和DNA序列测定,得到了73人的JC病毒DNA IG区域的碱基序列。多态分析研究结果表明,73人中的基因型分别由B1-a,B1-b,B1-c,CY和EU组成,各基因型所占比率为:4.1%,58.9%,8.2%,21.9%和2.7%。研究发现,在各基因型中B1-b型和CY型所占的比率高。通过NJ法进行了聚类分析法构建分子系统树,分析发现该人群JC病毒基因型中广泛分布于欧亚大陆中心的B1-b型占优势,其次是分布于亚洲东北部的CY型。

The article held a comparison to the geographical distrihutio.n of genotype in IG region of JC polyomavirus of Uighur people in Xinjiang. We separated JC virus from 103 samples of male Uighur donors who are over 40 years old, and also extracted DNA from these sample, we also held PCR experiment the IG region of JC virus and mensurated DNA sequence, and obtained the base sequence of IG region of JC virus of 73 people. Many figures analysis research indented that the 73 people of base sequence, showed that 5 genotypes Bl--a, Bl--b, BI--c, CY and EU were present with frequencies of 4.1%, 58.9%, 8. 2%, 21.9% and 2.7%, respectively. Genotype Bl--b was found in the most of the sampled areas and was dominant in Xinjiang, this analysis linked the Uighur people to the Turkish populations that history shows as moving south from the Mongolian Highlands. They were described as Turks around the third century BC.