血清胃蛋白酶原及其亚群对胃癌早期诊断的应用价值

Application Value of Serum Pepsinogen Ⅰ, Ⅱ in the Early Diagnosis of Gastric Cancer

目的：通过时胃癌患者血清胃蛋白酶原PG及其亚群PGⅠ、PGⅡ的测定，探讨血清PGⅠ、PGⅡ及PGⅠ／PGⅡ（PGR）比值对胃癌早期诊断的关系。方法：运用乳胶增强免疫比浊法测定30例胃癌患者和20例正常对照空腹血清PGⅠ、PGⅡ的含量及PGR值，并进行比较统计学分析。结果：胃癌患者组血清PGⅠ含量及PGⅠ／PGⅡ（PGR）比值（36．65±12．79ng／ml;3．16±0．76）明显低于正常对照组（50．16±13．24ng／ml;5．26±0．88），有显著性差异。结论：监测血清PGⅠ及PGⅠ／PGⅡ（PGR）比值变化对胃癌的早期诊断有重要的临床意义，可望作为胃癌早期筛选的指标。

Objective： Through the determination of serum PG Ⅰ , PC, Ⅱ of gastric cancer patients, to explore the serum PG Ⅰ , PGⅡ and the PG Ⅰ/PGⅡ （PGR） levels＇ clinical significance in the early diagnosis of gastric cancer. Methods： Test the serum PG Ⅰ , PGⅡ and PGR levels of 30 cases of patients of gastric cancer and 20 cases of healthy people with latex enhanced immunoturbidimetric assay. Compare the results and make statistical analysis. Results： Serum PG Ⅰ , PGR levels in gastric cancer group （46.65±22.79 ng/ml; 3.97±1.86） were obviously lower than the normal group （50.16±17.24 ng/ ml; 5.66±1.08）. Conclusion： The test of serum PG Ⅰ , PGR level has important clinical significance in early diagnosis of gastric cancer.