离心造粒法制备双嘧达莫缓释微丸

Preparation of Sustained-release Pellets of Dipyridamole Using Centrifugal Granulation Method

目的制备双嘧达莫缓释微丸,考察包衣量对体外释放度的影响。方法采用离心造粒法制备双嘧达莫缓释微丸。结果所得的微丸圆整度良好,Eudragit NE30D包衣增重为7%时,所得微丸表现出缓释特征,相对生物利用度为(104.7±17.2)%,与参比制剂相比吸收程度等效,吸收速度不等效。结论离心造粒法适全双嘧达莫缓释微丸的制备。

Objective To prepare dipyridamole pellets and investigate the effects of the coating amount on the in vitro release of the pellets. Methods The pellets were prepared by centrifugal granulation method. Results The pellets coated with 7% Eudragit NE30D amount had a sustained - release property with a bioavailability （104. 7 ± 17.2）%, showing equivalence to reference tablets in absorption degree rather than in absorption velocity. Conclusion The dipyrida mole pellets were successively prepared by centrifuge granulation method.