无创机械通气在重症急性胰腺炎中的应用

Clinical Application of Noninvasive Ventilation in Emergency Treatment for Severe Acute Pancreatitis with Acute Respiratory Failure

目的观察重症急性胰腺炎并发急性呼吸衰竭患者应用无创呼吸机辅助通气(Non invasive ventila-tion,NIV)后的临床疗效,为进一步研究重症急性胰腺炎的治疗方法奠定基础。方法对69例重症急性胰腺炎患者在常规治疗仍并发低氧血症时加用无创通气,检测应用前后的呼吸频率(RR)与动脉血氧饱和度(SpO2)、动脉血氧分压(PaO2)、pH、氧合指数(O I)等参数,观察其临床疗效。结果51例经加用NIV治疗后RR明显减慢(P<0.05)、SpO2、PaO2和氧合指数等均明显改善(P<0.05),pH恢复正常(P<0.05)。结论无创通气治疗重症急性胰腺炎并发急性呼吸衰竭患者可有效改善患者的呼吸状态,促进呼吸功能的恢复,是抢救早期重症急性胰腺炎患者安全有效的治疗方法。

Objective To investigate the clinical efficiency of severe acute pancreatitis with acute respiratory failure after using noninvasive ventilation（NIV） ,so as to provide the basis for further study on the therapy of severe acute pancreatitis. Methods Noninvasive ventilation was applied to 69 patients when conventional therapy was inefficacy. The values of parameters,the respiratory rate （RR） and arterial oxygen saturation （ SpO2 ）, arterial oxygen tension （ PaO2 ）, pH, oxygenation index （OI） were measured before and after treatment. Results The RR were dropped obviously （ P 〈 0.05）, SpO2 ,PaO2 and PaO2 FiO2 were improved significantly（ P 〈 0.05） ,pH was returned to normal condition（ P 〈0.05） after ventilating for 1 hour in 51 of 69 patients. Conclusion Noninvasive ventilation is a sate and ettective method in treating severe acute panereatitis with acute respiratory failure. It can improve the patients＇ respiratory conditions and promote respiratory function.