免疫系统在乙型、丙型病毒性肝炎发病过程中作用研究进展

Progression Of Research On The Immune System In Viral Hepatitis B、Hepatitis C Liver Damage

乙型病毒性肝炎和丙型病毒性肝炎分别由乙型肝炎病毒和丙型肝炎病毒感染所致。乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)感染呈全球分布,我国是高流行地区,由于HBV、HCV基因的高变性,容易逃避机体免疫系统的清除。HBV、HCV感染免疫系统细胞,造成机体对HBV、HCV感染的免疫应答异常,并引起组织的损伤,导致肝细胞的慢性持续性感染,并可进一步发展成肝硬化,甚至肝细胞肝癌。HBV、HCV主要经血液传播,包括输血与血制品传播、静脉吸毒、针刺、医源性传播、性接触和母婴垂直传播。

Viral hepatitis caused by hepatitis virus infection.Hepatitis B virus（HBV）.hepatitis C virus（HCV） infection was the global distribution. HBV and HCV in our country is a high-endemic.HBV and HCV infected cells in the immune system,resu-lting in abnormal immune response in the body of HBV,HCV and cause organiz-ations injury,lead to liver cells infected chronic persistently,and further develop into liver cirrhosis and even hepatocellular carcinoma.HBVand HCV is spread mainly by blood,including the spread of blood transfusion and blood products,intravenous drug abuse,acupuncture, iatrogenic transmission,sexual contact and mother-to-child vertical transmission.