急性心肌梗死患者冠脉病变程度与B型利钠肽相关性研究

Relationship between the Extent of Coronary Artery Lesions and BNP

目的:分析非心衰急性心肌梗死患者冠脉病变程度与血浆B型利钠肽(BNP)水平有无相关性及其临床意义。方法:选取非心衰急性心肌梗死患者66例,对照组为冠脉造影排除冠心病诊断者24例。冠脉造影前测定各组BNP水平,将冠脉病变程度与BNP水平进行相关性分析,并对不同梗死部位的BNP水平进行比较。所得数据采用SPSS17.0统计软件进行分析。计量资料采用(均数±标准差)表示,应用t检验进行分析。BNP与冠状动脉评分之间采用Pearson相关系数进行检验。P<0.05为显著性差异。结果:急性心肌梗死组BNP水平显著高于非冠心病组(P<0.001)。血浆BNP水平与冠脉病变评分呈正相关关系,相关系数为r=0.048。结论:在排除心衰因素后,急性心肌梗死患者冠脉病变程度越重,BNP水平越高。BNP测定有助于急性心肌梗死患者的危险分层及预后判断。

Objective： To explore the relationship between the extent of coronary artery lesion and plama B-type natriuretic peptide （BNP） levels in patients with acute myocardial infarction（AMI） except for heart failure（HF）. Method： 66 AMI patients without HF were enrolled in the study. 24 patients with normal coronary arterography（CAG） served as controls. Plasma BNP levels were measured before CAG. Compare the correlation between BNP and the extent of coronary artery lesions, as well as BNP levels between different infartion site. All statistical analysis was carried on via SPSS17.0 version in personal computer. The data were expressed as （meantSD） and were analyzed by using t-test . Bi-variance correlation was evaluated by Pearson Correlation Coefficiant. P〈0.05 indicated statitical significance. Result： The plasma BNP concentrations in patients with AMI were significantly higer than those in controls （P〈 0.001 ） . There was a positive correlation between the BNP levels and coronary artery lesion score （r=0.048）. Conclusions： AMI patients without heart failure, the more serious the coronary artery lesions, the higher the plasma BNP concentrations were. BNP may be helpful for the risk stratification and prognosis determination of AMI patients.