奥硝唑缓释膜生物学性能的初步研究

Preliminary study on the biological characters of Ornidazole Slow-Release Membrane

目的检测奥硝唑缓释药膜的生物相容性、抑菌性进行初步的生物学评价。方法1.12只大鼠下唇分别被缝成一盲袋,每日注入药膜浸提液,第7天做病理检查;2.于16只大鼠脊柱两侧肌肉内分别埋植药膜和手术丝线,第1,2,4,6周做病理检查。3.固体培养基体外抑菌法观察药膜对变形链球菌和具核梭杆菌的抑菌性。结果药膜无口腔黏膜刺激性,肌肉埋植后的周围组织反应与丝线相似,药膜第2周已降解;对所测致病菌有良好的抑菌性。结论奥硝唑缓释药膜具有良好的组织相容性和抑菌性,在临床有广阔的应用前景。

Objective To evaluate the biocompatibility and antibacterial activities of the Ornidazole Slow-Release Membrane. Methods 1. The lower lips of 12 rats were sewed into 12 pockets and the pockets were immited with extracting solution of the ornidazole membrane, formaldehyde and normal saline respectively once per day. The specimens were examined histologically 7 days later. 2. The dorsal muscles of 16 rats were implanted with the membranes or silk threads, and examined histologically 1 week and 2, 4, 6 weeks later respectively. 3. The antibacterial activity against Streptococcus mutans and Fusobacteriurn nucleatum was observed on solid culture medium in vitro. Results The animal experiments showed the membranes were not irritative to the oral mucosa. It was found that the tissue reaction of the membranes was similar to that of the silk threads after implanted into dorsal muscles and the membranes had been degraded in the second week. And the membranes had effective antibacterial action against Streptococcus mutans and Fusobacterium nucleatum. ConclusionThe Ornidazole Slow-Release Membrane possesses favorable biocompatibility and antibacterial activities.