毒性弥漫性甲状腺肿患者生存质量及其影响因素分析

Study on the quality of life and its influencing factors in patients with diffuse toxic goiter

目的探讨影响毒性弥漫性甲状腺肿（GD）患者生存质量的社会及临床因素。方法采用自编调查问卷和简明健康调查量表（SF-36），对确诊的66例GD患者和66例正常对照人群进行调查和测量分析。结果测得GD患者SF-36量表8个维度的得分低于正常对照组，并且均差异有显著性（P〈0．05）。其中GD患者要和正常对照组得分生理功能为[（70．45±19．25）分，（92．8±6．51）分，t=8．898，P=0．001]；生理角色限制为[（39．42±39．00）分，（90．97±21．67）分，t=8．582，P=0．001]；躯体疼痛为[（79．36±19．18）分，（85．98±12．88）分，t=2．453，P=0．017]；社会功能为[（75．95±19．46）分，（83．79±13．17）分，t=4．457，P=0．001]；情感职能为[（37．88±40．04）分，（71．21±41．30）分，t=5．732，P=0．001]；精神健康为[（52．91±17．31）分，（68．67±13．33）分，t=4．519，P=0．001]。SF-36总分、生理健康综合得分和心理健康综合得分均与年龄、文化程度、临床症状计数正相关（P〈0．05）。GD患者的生存质量与文化程度呈正相关，与临床症状计数、年龄呈负相关。结论GD患者生存质量明显下降，影响GD患者生存质量的主要因素是临床症状计数、年龄和文化程度。

Objective To compare the quality of life of the patients with diffuse toxic goiter （GD） and normal controls using 36-item Short Form Health Survey （SF-36） in Chinese, to explore the social and clinical factors which influence the quality of GD＇s life. Methods 66 patients and 66 normal controls were assessed using self-composing questionnaire and 36-item Short Form Health Survey （SF-36）. Results Scores of eight dimensions of quality of life were lower than that of health controls, had significantly differences than that of health controis. There were statistical significant differences in terms of the score difference of eight dimensions between the GD patients and normal controls（P〈 0.05 ）. The scores of physical functioning dimension in GD patients, normal controls were 70.45 ± 19.25,92.8 ± 6.51 （ P 〈 0.01 ） , respectively; in role physical dimension were 39.42 ±39.00,90.97 ±21.67 （ P 〈 0.01 ） ; in bodily pain dimension were 79.36 ±19.18,85.98 ±12.88 （ P 〈 0.01 ） ; in social functioning dimension were 75.95 ±19.46,83.79 ±13.17 （ P 〈 0.05 ） ; in role emotional dimension were 37.88 ±40.04,71.21 ±41.30 （ P 〈 0.01 ） ;in mental health dimensions were 52.91 ±17.31,68.67 ±13.33 （ P 〈 0.01 ）. The scores of dimensions were related with age, the number of clinical symptom, educational status. In GD group, the scores were positive related with educational status and clinical course;and negative related with age and the number of clinical symptom. Conclusion The quality of life were descend obviously in patients with Graves disease. The number of clinical symptom, age and educational status are the major social and clinical factors, which effected the quality of life of patients with Graves disease.