血浆同型半胱氨酸检测在肝硬化及肝癌患者中的临床价值

Detection of plasma homocysteine in patients with liver cirrhosis and liver cancer and its clinical value

目的:探讨血浆同型半胱氨酸(Hcy)检测在肝硬化及肝癌患者中的临床价值和肝硬化患者随访2年后血浆Hcy含量的变化。方法:检测137例肝硬化患者、43例肝癌患者和50例对照组的血浆Hcy水平,肝硬化患者随访2年后再次检测血浆Hcy含量,对检测结果进行统计分析。结果:肝硬化及肝癌组Hcy水平明显升高,具有统计学意义(P<0.05或P<0.01),肝硬化患者随着Child-Pugh分级的升高而递增,而且肝癌组与肝硬化各级之间比较,A级、B级差异非常显著(P<0.01),C级差异显著(P<0.05),肝硬化患者首次检测的Hcy含量与随访2年后检测的Hcy含量自身比较,Hcy略有增加,呈升高趋势,但无统计学意义(P>0.05)。结论:肝硬化及肝癌病人随着肝细胞损害程度的逐渐加重,血浆Hcy水平逐渐升高,血浆Hcy是反映肝损伤程度较为敏感的生化指标之一,并且对肝硬化及肝癌的诊断、治疗、预后判断具有一定的指导意义。

Objective：To investigate the plasma homocysteine（Hcy） detected in patients with liver cirrhosis and liver cancer and the clinical value in patients with liver cirrhosis were followed up for 2 years after the change in plasma Hcy concentration.Methods：137 cases of liver cirrhosis,43 cases of liver cancer patients and 50 control group,plasma Hcy levels in patients with liver cirrhosis after 2 years follow-up testing of plasma Hcy levels of the test results for statistical analysis.Results：The liver cirrhosis and liver cancer group was significantly increased Hcy levels,with statistical significance（P0.05 or P0.01）,liver cirrhosis patients with Child-Pugh classification and the incremental increase,and the group of liver cancer and liver comparison between the hardening at all levels,A-class,B-class difference was significant（P0.01）,C-level significantly different（P0.05）,first detected in patients with cirrhosis of the Hcy concentration and follow-up 2 years after the detection of Hcy content in their own comparison,Hcy increased slightly,the trend was rising,but no statistical significance（P 0.05）.Conclusion：Patients with liver cirrhosis and the extent of damage to liver cells gradually increase,gradually increased the level of plasma Hcy and plasma Hcy is a reflection of the degree of liver injury is more sensitive biochemical indicator of,and the diagnosis of liver cirrhosis and liver cancer,treatment,prognosis has some significance.