梅毒患者血清多种白细胞介素的检测及临床意义

Changes and clinical significance of levels of interleukin-detection in serum of symptomatic syphilitic patients

目的:观察不同期梅毒患者血清IL-2、4、6、10水平,探讨其在梅毒感染发生、发展中的意义。方法:选取显性梅毒患者80例,采用ELISA法检测血清IL-2、4、6、10含量,并以60例健康者作为对照组进行比较。结果:显性梅毒患者IL-2、IL-4、IL-6、IL-10均高于对照组,差异均有统计学意义(χ2=14.55、10.17、16.84、13.92,P<0.05);一期梅毒患者IL-2高于二期梅毒患者,但IL-4、IL-6、IL-10低于二期梅毒患者,差异均有统计学意义。IL-2与IL-4、IL-6、IL-10为负相关(r=-0.728、r=-0.709、r=-0.617,P<0.05);IL-4与IL-6、IL-10为正相关(r=0.812、r=0.902,P<0.05);IL-6与IL-10为正相关(r=0.748,P<0.05)。男性与女性IL-2、IL-4、IL-6、IL-10表达差异无统计学意义(均P>0.05);不同年龄段IL-2、IL-4、IL-6、IL-10表达差异有统计学意义(均P<0.05)。结论:梅毒感染者存在异常的细胞免疫应答,及其细胞因子分泌失调,联合检测IL-2、IL-4、IL-6、IL-10有助于分期判断与指导治疗。

Objective：Observed in patients with syphilis at different stages of serum IL-2,4,6,10 level to explore the syphilis infection in the occurrence and development of the meaning.Methods：Selected 80 cases of syphilis dominant,using ELISA assay of serum IL-2,4,6,10 content,and 60 cases of healthy persons as control group.Results：Syphilis in patients with autosomal dominant IL-2,4,6,10 were higher than,the differences were statistically significant（χ2=14.55,10.17,16.84,13.92,P0.05）;Syphilis in patients with an IL-2 higher than that in patients with secondary syphilis,but IL-4,IL-6,IL-10 than in patients with secondary syphilis,the differences were statistically significant.IL-2 and IL-4,IL-6,IL-10 for negative correlation（r=-0.728,r=-0.709,r=-0.617,P0.05）;IL-4 and IL-6,IL-10 for the positive correlation（r=0.812,r=0.902,P0.05）;IL-6 and IL-10 was positively correlated（r=0.748,P0.05）.Male and female IL-2,4,6,10 expression was no significant difference（all P0.05）;Different age groups IL-2,4,6,10 expression were statistically significant differences（all P0.05）.Conclusion：The existence of syphilis-infected cells,abnormal immune response,Cytokine secretion and its disorders.Combined detection of IL-2,IL-4,IL-6,IL-10 will help determine and guide the treatment of stages.