血清CG和ALT同步检测对肝病的诊断意义

Clinical significance of serum ALT and CG levels in patients with hepatitis

目的:探讨血清CG和ALT同步检测对肝病的诊断意义。方法:CG用RIA、ALT用全自动生化分析仪两次同步检测急肝162例,慢迁肝108例,慢活肝132例,肝硬化85例,肝癌55例及60例正常组。结果:急肝首检CG和ALT同步升高与正常组比较均具有极显著意义(P<0.001),在末次测定时ALT复常且CG也迅速转阴,两者比较无差异(P>0.05);慢活肝、肝硬化、肝癌则在后期ALT大多数回复正常时CG仍呈高水平,两者比较具有极显著性差异(P<0.001),肝癌组CG又显著高于急慢性非癌性肝病(P<0.001)。结论:血清CG和ALT同步检测更能全面反映肝病患者的肝脏整体病变,动态观察病情及区别良恶性肝病。

Objective：To explore the clinical significance of serum CG and ALT levels in patients with hepatitis.Methods：CG and ALT levels were determined by RIA and automatic biochemical analyzer,respectively.Simultaneous examination were done in 162 cases of acute liver,108 cases of slow to move liver,132 cases of slow living liver,85 cases of liver cirrhosis,55 cases of liver cancer and 60 cases of normal group.Results：Simultaneously increased CG and ALT levels are highly significant（P0.001）.compared with the normal group in the first seizure of acute liver group,whereas in the last examination ALT level turns normal and CG turns negative rapidly which showed no significant difference（P0.05）.CG levels stand high when ALT turns normal during later examination in the majority of slow living liver,liver cirrhosis and liver cancer samples,which exhibits extremely high significance（P0.001）.CG levels in liver cancer group are significantly higher than that of acute and chronic non-cancer liver disease（P0.001）.Conclusion：Simultaneous detection of serum CG and ALT can better reflect the whole liver lesions status in patients,assist dynamic observation of conditions and help to differ benign and malignant liver diseases.