妊娠高血压患者血小板参数及凝血功能相关指标的探讨

Pregnancy-induced hypertension in patients with platelet and coagulation parameters of relevant indicators

目的:(1)探讨妊娠高血压患者血小板及其参数检测的临床应用及意义;(2)探讨妊娠高血压患者凝血功能相关指标的临床应用及意义。方法:分别采用全自动血液分析仪(XT-2000i)和全自动血凝仪(CA-550)测定380例妊娠高血压患者和40例健康对照的血小板及其参数和凝血功能相关指标。结果:与健康对照组比较,妊娠高血压患者血小板计数(PLT)、凝血酶原时间(PT)和活化部分凝血酶原时间(APTT)差异显著(P<0.05),有统计学意义;纤维蛋白原(Fig)、平均血小板体积(MPV)、血小板分布宽度(PDW)和大血小板比率(P-LCR)差异有明显显著性变化(P<0.01),有统计学意义;而凝血酶时间(TT)差异不显著(P>0.05),无统计学意义。结论:监测妊娠妇女的血小板参数里的大血小板比率(P-LCR)、平均血小板体积(MPV)和血小板分布宽度(PDW)及凝血功能中纤维蛋白原(Fib)的变化,在诊断及防治妊娠高血压有重要意义。

Objective：（1） Explore pregnancy-induced hypertension patients and parameter test of platelet clinical application and significance;（2）Explore pregnancy-induced hypertension patients blood clotting related indexes of clinical application and significance.Methods：Respectively using automatic hematology analyzer（XT-2000i） and automatic blood clots（CA-550） 380 cases of 40 patients with hypertension patients and healthy controls the platelet function and its parameters and blood coagulation.Results：Compared with healthy controls,pregnancy-induced hypertension patients（PLT platelet count）,and prothrombin time（PT） and activation part prothrombin time（APTT） significant difference（P0.05）,a statistically significant,Fibrinogen（Fig）,average platelet volume（MPV）,platelets（PDW） and the distribution of big width of platelet ratio（P） has revealed differences LCR-change significantly（P0.01）,a statistically significant,And thrombin time（TT）,the difference was not significant（p0.05）,no statistical significance.Conclusion：Monitoring the parameters of the pregnant women of platelet platelet ratio（P）,average LCR-platelet volume（MPV） and platelets（PDW） and the width of the distribution of coagulant function of fibrinogen（Fib）,in the diagnosis and prevention pregnancy-induced hypertension has important significance.