2607例学龄前儿童乙肝病毒标志物检测结果分析

Analysis of HBV marker detection in 2607 preschool children

目的：了解我县在大力推广乙肝疫苗注射后3～6岁儿童乙肝病毒（HBV）感染情况。方法：于2009年3～6月对我县3～6岁入园儿童2607名,采用酶联免疫吸附试验（ELISA）检测血清中HBsAg、HBsAb、HBeAg、HBeAb、HBcAb。结果：总HBsAg阳性率为0.84%,总HBsAb阳性率为62.18%,HBsAb阴性率为36.98%,与经济欠发达城市相比,我县在降低儿童HBV感染率与提高其保护率方面效果令人满意。该批儿童感染模式共有7种。HBsAg、HBsAb阳性率,HB-sAb阴性率性别的差异无显著性。结论：乙肝疫苗是目前预防乙肝病毒感染的有力手段。如何最大可能地提高儿童乙肝疫苗接种率,提高免疫接种的HBsAg阳性率,加强乙型肝炎防治知识宣传,从而有效地控制和减少儿童HBV的传播,是广大医务工作者的一项重要任务。

Objective：To understand the county in addition to vigorously promote the hepatitis B vaccine 3 to 6 year-old children hepatitis B virus（HBV） infection.Methods：2009 3 June to the county for children 3 to 6 years of age for admission 2607,using enzyme-linked immunosorbent assay（ELISA） detection of serum HBsAg,HBsAb,HBeAg,HBeAb,HBcAb.Results：The total HBsAg positive rate of 0.84% and the total HBsAb positive rate of 62.18%,HBsAb-negative rate was 36.98 percent,compared with the less economically developed cities,county in reducing child HBV infection rate and increase its protective effect is satisfied.Batch mode of children infected with a total of 7.HBsAg,HBsAb-positive rate,HBsAb-negative rate of gender difference was not significant.Conclusion：Hepatitis B vaccine to prevent hepatitis B virus infection is a powerful tool.How do the greatest possible way to improve children′s hepatitis B vaccination coverage,and increasing immunization of HBsAg-positive rate of hepatitis B prevention and control knowledge to strengthen advocacy,so as to effectively control and reduce the spread of HBV children,the vast number of medical workers is an important task.