青田县健康人群中乙型肝炎病毒感染率调查

Epidemiological investigantion of heptitis B virus infection frequency in healthy populations of Qingtian County

目的：了解我县健康人群中乙型肝炎病毒（HBV）感染率及其模式,探讨预防乙肝的对策与措施。方法：采取整群抽样及ELSIA法,检测我县城乡不同年龄、性别人群血清中乙肝病毒标志物HBsAg、HBeAg、HBsAb、HbeAb和HBcAb。结果：HBV总感染率65.77%（269/409）,五项检测指标均阴性140例,占34.23%。各血清学检测阳性指标中有6种构成模式：单项HBsAb阳性（36.43%）、单项HBcAb阳性（9.29%）、HBsAb和HBcAb阳性（14.3%）、HbsAg和HBcAb阳性（1.17%）、HBsAg和HBeAb及HBcAb阳性（3.18%）、HBsAg和HBeAg及HBcAb阳性（0.73%）。1～4岁组人群中无HBsAg阳性,5～14岁、15～59岁和60～岁组HBsAg阳性率较高（3.74%、11.01%和5.62%）（P〈0.01）。人群中HBsAb总阳性率为50.86%,无年龄、性别及城乡差异（P〉0.05）。15～59岁和60～岁组人群中HBcAb阳性率（54.13%和49.02%）明显高于1～4岁和5～14岁组（2.20%和6.54%）（P〈0.05）。结论：接种乙肝疫苗...

Objective：To determine the frequency and pattern of heptitis B virus infection in Qingtian county,and to approach the strategy and measure for heptitis B prevention.Methods：By using cluster sampling and ELISA,the HBV markers HbsAg,HbeAg,HbsAb,HbeAb and HbcAb in sera of populations with different ages from town or rural area in Qingtian county.Results：The total HBV infection rate was 65.77%（269/409） while 34.23% of them（140/409） was negative for all the tested markers in the populations.There were six patterns among the serologically positive markers： positive for HBsAb（36.43%） or HbcAb（9.29%） alone,positive for both HbsAb and HbcAb（14.3%） or for both HbsAg and HbcAb（1.17%）,positive for HbsAg,HbeAb and HbcAb（3.18%） or HbsAg,HbeAg and HbcAb（0.73%）.No HbsAg positive cases could be found in the individuals with 1~4 ages but higher HbsAg positive rates were presented in the individuals with 5~14,15~59 and 60~ ages（3.74%,11.01% and 5.62%）（P0.01）.The total HbsAb positive rate was 50.86% with no age,sex and regional differences（P0.05）.The HbcAb positive rates in subpopulations with 15~59 and 60~ ages（54.13% and 49.02%） were significantly higher than those in subpopulations with 1~4 and 5~14 ages（2.20%和6.54%）（P0.05）.Conclusion：Innoculation with heptitis B vaccine enables the desrease of HBV infection frequency in children and the difference of HBV infection frequencies between populations from town and rural areas becomes much lower.However,adults should be reinforced for the vaccination because of the raletively higher HBV infection rate in the population.