多层螺旋CT灌注成像在胰腺癌诊断中的应用

The Application of MSCT Perfusion in Diagnosis of Pancreatic Carcinoma

目的:探讨MSCT灌注成像在胰腺癌诊断中的作用。方法:对正常组16例和术后经病理证实为胰腺癌的肿瘤组30例行MSCT灌注成像扫描,分析正常胰腺与胰腺癌MSCT灌注特点,分别测量血流量(BF)、血容量(BV)、平均通过时间(MTT)、表面通透性(PS)等灌注参数,并进行统计学分析。结果:正常组BF、BV、MTT和PS值分别为(3864.6±413.7)mL·min^(-1)·kg、(282.6±128.5)mL/kg、(7.54±3.83)S、(281.4±83.7)mL·min^(-1)·kg。肿瘤组BF、BV、MTT和PS值分别为(2056.2±532.1)mL·min^(-1)·kg^(-1)、(176.3±162.3)mL/kg、(8.12±2.95)S、(436.5±79.3)mL·min^(-1)·kg^(-1)。两组的BF、BV和PS平均值差异具有显著性意义(BF:P<0.01,BV:P<0.05,PS:P<0.01);MTT平均值差异无显著性意义(P>0.05)。结论:MSCT灌注成像对胰腺癌诊断具有重要价值,为临床手术提供先期指导。

Objective To evaluate the roles of MSCT perfusion imaging in diagnosis of pancreatic carcinoma. Methods MSCT perfusion scanning was performed in 30 patients（tumor group）, who were confirmed pancreatic cancer by pathology, and in 16 patients（normal group） without pancreatic disorders served as controls.The perfusion characteristics of normal pancreas and pancreatic carcinoma were analyzed.The data of MSCT perfusion parameters,including blood flow（BF）, blood volume （BV）. mean transit time（MTT）, permeability surface（PS）, were measured and analyzed statistically. Results The mean BF, BV, MTT and PS in normal group were respectlvely（3864.6±413.7）mL·min^-1·kg^-1, （282.6±128.5）mL/kg, （7.54±3.83）s, （281.4±83.7） mL·min^-1·kg^-1 .Tumor group BF, BV, MTT and PS values were （2056.24-532.1）m·min^-1·kg^-1. （176.3±162.3） mL/kg, （8.12±2.95）s,（436.5±79.3） mL·min^-1·kg^-1, respectively. The mean BF, BV and PS between pancreatic carcinoma and normal pancreas were statistically significant （BF：P 〈 0.01, BV：P 〈 0.05, PS：P 〈 0.01）. However, the mean MTT between two groups was not statistically significant（P 〉 0.05）. Conclusion MSCT perfusion imaging for diagnosis of pancreatic cancer has an important value,to provide early guidance for clinical surgery.