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腺苷酸活化蛋白激酶在酒精性肝病中的研究进展

Studies on AMP-activated protein kinase and alcoholic liver disease
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摘要 腺苷酸激活蛋白激酶(AMPK)信号通路是调节细胞能量状态的中心环节,其激活后磷酸化下游的信号分子,抑制ATP合成,同时促进ATP分解,被称为"细胞能量调节器",在增加脂肪酸氧化、胰岛素敏感性及氧化应激等方面发挥重要作用,可能参与酒精性肝病的发病过程。该文就AMPK在酒精性肝病发病机制中的作用作一综述。 The AMP-activated protein kinase （AMPK） acts as a sensor of cellular energy status. Once being activated, AMPK switches on catabolic pathways that generate ATP, while switching off ATP consuming processes. It plays an important role in increasing fatty acid oxidation, insulin sensibility and oxidative stress. It can take part in the pathogenesis of alcoholic liver disease （ALD）. In this review, we summarized the role of AMPK in the Dathozenesis of ALD.
作者 魏峰 周俊英
机构地区 河北医科大学第三医院感染科
出处 《国际内科学杂志》 CAS 2009年第12期726-729,共4页 International Journal of Internal Medicine
关键词 腺苷酸激活蛋白激酶 酒精性肝病 胰岛素抵抗 AMP-activated protein kinase Alcoholic liver disease Insulin resistance
分类号 R575 [医药卫生—消化系统]
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国际内科学杂志
2009年 第12期

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