重症登革热的研究进展

Advances of research on severe dengue

登革热是流行于全球尤其是热带亚热带地区的急性传染病,其中有重症表现的登革热是引起登革热患者死亡的主要原因,但是由于目前WHO关于登革热分类的缺陷,使得重症登革热发生率被低估,已经有越来越多的中外学者对WHO定义的登革热分类提出质疑,提出了重症登革热的概念并得到认可。文章主要对重症登革热的临床表现、流行情况、危险人群、危险指标等最新研究进展进行综述,以提高人们对重症登革热的认识,为制定新的登革热诊断标准和治疗方案提供理论基础。

Dengne fever is an acute infectious disease which spreads worldwide, especially in tropics and subtropical areas. Dengue hemorrhagic fever and severe dengue is the main reason leading to the death of dengue fever cases. Dut due to the defect of the classification of dengue fever determined by WHO, dengue fever cases with severe symptom was underestimated. More and more domestic and foreign scholars had questioned the WHO classification and proposed the concept of severe dengue. This article reviewed the latest advance researches about clinical manifestation, prevalence, population at risk, and risk indicator of severe dengue, in order to improve people＇s awareness of severe dengue, to provide base theories for deciding the new diagnostic criteria and new therapeutic schedule of dengue fever.