小儿过敏性紫癜尿IgG测定的临床意义

Clinical significance of lgG determination in children with Henoch-Schonlein purpura

目的了解尿IgG检测在诊断过敏性紫癜(HSP)患儿早期肾损害中的作用。方法对188例过敏性紫癜(HSP)患儿、99例紫癜性肾炎(HSPN)、26例对照组进行尿IgG检测;同时,对188例过敏性紫癜患儿进行尿蛋白定性检测。结果 HSP组尿IgG异常率远高于尿蛋白定性的异常率(P<0.05);HSP组尿IgG浓度高于对照组(P<0.05),HSPN组尿IgG浓度高于HSP组(P<0.05)。结论尿IgG检测简单,无损伤性,对发现过敏性紫癜患儿早期肾损伤有很高价值。

Objective To investigate the role of IgG determination in diagnosis of early renal damage in children with Henoch-schonlein purpura（HSP）. Methods Urine IgG was determined in 188 children with HSP （HSP group）, 99 patients with Henoch-sehonlein purpura nephritis （HSPN group） and 26 healthy controls （healthy control group）. Simultaneously, qualitative detection of urine protein was carried out in HSP group. Results The abnormality rate of urine IgG was significantly higher than that of urine protein in HSP group （P〈0.05）. The level of urine IgG was significantly higher in HSP group than that in healthy control group （P〈0.05）, while the level of urine IgG in group than that in HSP group （P〈0.05）. Conclusion Urine IgG determination is simple and nonin vasive, which if high clinical value in diagnosis of early renal damage in children with Henoch-sehon lein purpura（HSP）.