摘要
目的:研究正丁胺基罗沙替丁乙酸酯(BRA)对幽门结扎型胃溃疡大鼠胃液成分的影响。方法:采用幽门结扎法制备胃溃疡模型,测定大鼠溃疡指数及胃液分泌量。结果:BRA组溃疡指数、胃液、胃酸分泌量明显降低,胃蛋白酶活性也降低(P<0.01)。结论:BRA对实验性胃溃疡有促进溃疡愈合、保护胃黏膜的作用。
Objective：To study the effects of Butylamine Roxatidine Acetas （BRA） on gastric juice excretion in rats with the pyloric ligation ulcer. Methods：The pyloric ligation ulcer models were prepared,then the ulcer index and gastric juice secretion of rats were determined. Results：The ulcer index,gastric juice and gastric acid secretion of BRA group were decreased,and the pepsin activity was significantly reduced （P0.01）. Conclusion：BRA shows effects of promoting ulcer healing and protecting gastric mucosa on experimental gastric ulcer.
出处
《中国医药导报》
CAS
2009年第36期19-20,共2页
China Medical Herald
关键词
正丁胺基罗沙替丁乙酸酯
胃溃疡
胃黏膜保护作用
Butylamine Roxatidine Acetas （BRA）
Gastric ulcer
Protective effects on gastric mucosa
