血清胱抑素C、超敏C-反应蛋白在2型糖尿病并发症中的意义

Significance of the determination of serum cystatin C and high-sensitivity Creactive protein in the complications of T2DM

目的:探讨血清胱抑素C(CysC)及超敏C-反应蛋白(hsCRP)联合检测对糖尿病患者早期慢性并发症的临床诊断价值。方法:采用全自动生化分析仪测定65例2型糖尿病(T2DM)患者(DM组)和50例正常健康人(对照组)的CysC与hsCRP含量。结果:DM组血清CysC和hsCRP水平明显高于对照组(P<0.01),血清CysC在DM组的特异性高于hsCRP,但敏感性不如hsCRP。CysC和hsCRP呈明显正相关(r=0.631,P<0.05)。结论:CysC及hsCRP是糖尿病早期肾病和并发心血管事件的敏感指标,联合检测可以提高敏感性和特异性。

Objective：To investigate the early clinical diagnosis in the chronic complications of T2DM patients with com bined detection of serum CysC and hsCRP. Methods：Serum CysC and hsCRP levels were determined in 50 normal healthy people （control group） and 65 patients with T2DM （DM group） with automatic biochemical analyzer. Results：Serum CysC and hsCRP levels of DM group were significantly higher than the control group （P0.01）,serum CysC of DM group had a higher level of specificity than hsCRP,but less sensitive than hsCRP. CysC and hsCRP was positively correlated （r=0.631,P0.05）. Conclusion：CysC and hsCRP are sensitive indicators in early diabetic nephropathy and cardiovascular events,the combined detection can improve the sensitivity and specificity.