水蛭胶囊对颈动脉斑块稳定性及血小板膜糖蛋白分子表达的影响

Effect of Leech Capsule on stability of carotid plaque and expression of platelet membrane glycoprotein

目的:探讨水蛭胶囊对脑动脉硬化症患者颈动脉斑块稳定性及血小板膜糖蛋白分子表达的影响。方法:选择203例伴颈动脉不稳定斑块的脑动脉硬化症患者,随机分为2组:观察组101例在常规治疗基础上加用水蛭胶囊治疗,对照组102例除常规治疗外不予其他治疗。观察两组患者治疗前后颈动脉内-中膜厚度(IMT)、斑块面积、不稳定斑块数量和血小板膜糖蛋白Ⅱb/Ⅱa复合物(PAC-1)、选择素P(CD62P)阳性率变化。结果:治疗后与对照组比较,观察组IMT、斑块面积、不稳定斑块数量和PAC-1、CD62P阳性率下降显著。而对照组IMT、CD62P下降不明显。未见水蛭胶囊有明显的毒副作用。结论:水蛭胶囊有助于颈动脉斑块稳定,降低血小板活化程度,副作用少,值得进一步推广。

Objective：To investigate the effect ofLeech Capsule on stability ofcarotid plaque and expression ofplatelet membrane glycoprotein in patients with cerebral arteriosclerosis.Methods：203 patients with cerebral arteriosclerosis which with unstable carotid plaque were divided into two groups.There were 101 patients in observation group which were treated by conventional therapy and Leech Capsule, and 102 patients in control group which were treated only by conventional therapy.Then comparison analysis ofIMT, plaque area, unstable plaque number and positive rates ofPAC-1 and CD62P were made before and after treatment with two groups.Results：After treatment, the IMT, plaque area, unstable plaque number and positive rates ofPAC-1 and CD62P in observation group were significantly lesser than those in control group.In observation group, all parameters after treatment were significantly lesser than those before treatment, but in control group there were no significant difference in IMT and positive rates ofCD62P between after treatment and before treatment.In addition, there were no obvious adverse reactions after treatment by leech capsule.Conclusion：Leech Capsule was an effective drug for stabilizing carotid plaque and depressing the level ofplatelet activation, and it had few adverse reaction.It was worth further spreading.