摘要
目的:探讨缺血修饰白蛋白(IMA)对急性冠脉综合征(ACS)早期诊断的临床应用价值。方法:通过白蛋白钴结合试验(ACB法)检测117例疑似ACS急性胸痛患者和30例健康体检者(健康对照组)的血清IMA水平(即ACB值),并与传统诊断工具比较,评价IMA对ACS的早期诊断效能。结果:ACS组的ACB值为54.73±6.36U/ml,明显低于非缺血性胸痛(NICP)组和健康对照组(P<0.001)。取区分ACS和NICP最适cutoff值(临界值)=63.80U/ml,此时曲线下面积为0.875,敏感度为86%,特异度为47%。IMA对ACS诊断的敏感度和阴性预测值明显高于心电图(ECG)和肌钙蛋白I(cTnI),而联合应用IMA进行诊断后其敏感度和阴性预测值较单独应用ECG和cTnI明显提高。结论:IMA可用于疑似ACS急性胸痛患者的早期诊断。
Ohjective:To study the clinical value of ischemia modified alhumin (IMA) for early diagnosis in acute coronary syndrome (ACS). Methods:We detected the IMA levels (ACB value) by albumin cobalt binding (ACB) test in 117 patients with acute chest pain and 30 healthy controls, and then compared the diagnostic values with traditional tools in ACS. Results: ACB valus of ACS (54. 73 ± 6. 36 U/ml) was significantly less than that in NICP and healthy control group(P〈0.001). At a cutoff value = 63.80 U/ml, the area under the ROC curve were 0. 875, sensitivity and specificity were 86% and 47% respeetively. The sensitivity and the negative predictive value of IMA was significently higher than those of ECG and cTnI. When IMA was used in combination , the sensitivity and the negative predictive value were significantly greater than them used alone. Conclusion: IMA can be used in the early diagnosis of ACS among the suspected patient with chest pain .
出处
《陕西医学杂志》
CAS
2009年第12期1624-1627,共4页
Shaanxi Medical Journal