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缺血修饰白蛋白对急性冠脉综合征早期诊断的临床应用 被引量:1

Clinical research of ischemia modified albumin in the early diagnosis of acute coronary syndrome
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摘要 目的:探讨缺血修饰白蛋白(IMA)对急性冠脉综合征(ACS)早期诊断的临床应用价值。方法:通过白蛋白钴结合试验(ACB法)检测117例疑似ACS急性胸痛患者和30例健康体检者(健康对照组)的血清IMA水平(即ACB值),并与传统诊断工具比较,评价IMA对ACS的早期诊断效能。结果:ACS组的ACB值为54.73±6.36U/ml,明显低于非缺血性胸痛(NICP)组和健康对照组(P<0.001)。取区分ACS和NICP最适cutoff值(临界值)=63.80U/ml,此时曲线下面积为0.875,敏感度为86%,特异度为47%。IMA对ACS诊断的敏感度和阴性预测值明显高于心电图(ECG)和肌钙蛋白I(cTnI),而联合应用IMA进行诊断后其敏感度和阴性预测值较单独应用ECG和cTnI明显提高。结论:IMA可用于疑似ACS急性胸痛患者的早期诊断。 Ohjective:To study the clinical value of ischemia modified alhumin (IMA) for early diagnosis in acute coronary syndrome (ACS). Methods:We detected the IMA levels (ACB value) by albumin cobalt binding (ACB) test in 117 patients with acute chest pain and 30 healthy controls, and then compared the diagnostic values with traditional tools in ACS. Results: ACB valus of ACS (54. 73 ± 6. 36 U/ml) was significantly less than that in NICP and healthy control group(P〈0.001). At a cutoff value = 63.80 U/ml, the area under the ROC curve were 0. 875, sensitivity and specificity were 86% and 47% respeetively. The sensitivity and the negative predictive value of IMA was significently higher than those of ECG and cTnI. When IMA was used in combination , the sensitivity and the negative predictive value were significantly greater than them used alone. Conclusion: IMA can be used in the early diagnosis of ACS among the suspected patient with chest pain .
出处 《陕西医学杂志》 CAS 2009年第12期1624-1627,共4页 Shaanxi Medical Journal
关键词 冠状动脉疾病/诊断 白蛋白类/血液 对比研究 Coronarydisease/diagnosis Albumins/blood Comparaive
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  • 1Roy D, Quiles J, Aldama G, et al. Ischemia Modified Albumin for the assessment of patients presenting to the emergency department with acute chest pain but non-diagnostic 12-lead electrocardiograms and negative cardiac troponin T . Int J Cardiol, 2004,97 : 297-301.
  • 2不稳定性心绞痛诊断和治疗建议[J].中华心血管病杂志,2000,28(6):409-412. 被引量:2696
  • 3高润霖.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725. 被引量:4988
  • 4Christenson RH, Duh SH, Sanhai WR, et al. Characteristics of an Albumin Cobalt Binding Test for assessment of acute coronary syndrome patients: a multicenter study. Clin Chem , 2001,47 : 464-470.
  • 5Fruergaard P. The diagnoses of patients admitted with acute chest pain but without myocardial infarction. Eur Heart J,1996,17 : 1028-1034.
  • 6Wu AH , Morris DL , Fletcher DR , et al. Analysis of the Albumin Cobalt Binding ACB test as an adjunct to cardiac troponin Ifor the early detection of acute myocardial in faretion. Cardiovasc Toxieol , 2001 , 1: 147-151.
  • 7Panteghini M. Role and importance of biochemical markers in clinical cardiology. Eur Heart J , 2004, 25: 1187-1196.
  • 8Sinha MK, Roy D , Gaze DC, et al. Role of "Ischemia modified abumin" , a new biochemical marker of myocardial ischemia , in the early diagnosis of acute coronary syndromes. Emerg Med J ,2004,21:29-34.
  • 9Frank P, Deborah L, Saif Anwaruddin, et al. Metaanalysis of ischemia modified albumin to rule out acute coronary syndromes in the emergency department. Am Heart J, 2006,152 : 253-262.
  • 10Collinson Po, Gaze DC, Baibridge K, et al. Utility of admission cardiac troponin and "Ischemia Modified Albumin'measurements for rapid evaluation and rule out of suspected acute myocardial infarction in the emergency department, Emerg Med J, 2006, 23: 256- 261.

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