蛋白质柔性区间的预测方法研究进展

Advances in the Research on the Methods of Prediction of the Flexible Rigions in Protein

蛋白质的柔性区间是蛋白质与其它分子结合所必需的结构,是蛋白质发挥正常功能的关键因素。不同的预测方法对柔性区间的定义有所不同。文章试图对几种较为重要的预测方法进行简要的介绍。

The flexible rigion plays the key role in the motion of molecular and the normal function of protein. For example, the activity of most enzymes depends on the flexible rigion, and the conformation of the flexible rigion usually determines the 3D-structure of the entire molecule. Besides, the application of the flexible rigion also means a lot in the Computer-Assisted Drug-Design. Thus the prediction of the flexible rigion of protein becomes one of the most interesting areas in the research of bioinformatics. The methods of prediction of the flexible tiglon of protein still need to be studied, which include the experimental method and bioinformatic method. The bioinformatic method is cheaper and more conveniet than the other methods, so it becomes the most hopeful in the future. The prediction of flexible tiglon of protein by the bioinformatic method started in 1980s. Many algorithms have been used in the prediction. But different algorithms do not get the same result because of different definition of the flexible rigion in potein. Predicting with the help of URMSD is very popular nowadays. This article tries to explain several definitions of flexible rigions in protein, and to introduce the development of bioinformatic method in the prediction and a few important algorithms in the prediction.