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表面活性蛋白A基因单核苷酸多态性与成年女性尿路感染易感性的关系 被引量：3

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摘要 在反复发作的尿路感染（UTI）患者中，只有部分患者存在明显的易感或诱发因素。目前尿路上皮细胞的天然免疫功能在UTI中的作用逐渐引起了关注^[1]。表面活性蛋白A（SP-A）是最早发现于肺组织的一种天然免疫分子，在肺部的宿主免疫和炎性反应调节方面起着重要作用；其基因的遗传变异导致了人群对多种肺部疾病不同的易感性^[2]。
作者 刘娇 梁伟 丁国华 王桂荣
机构地区 武汉大学人民医院肾内科 美国宾夕法尼亚州立大学医学院细胞和分子生物学系
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2009年第12期943-945,共3页 Chinese Journal of Nephrology
基金 国家自然科学基金（30670985）.
关键词 表面活性蛋白 感染易感性 尿路感染 单核苷酸多态性 A基因 成年女性 天然免疫功能 天然免疫分子
分类号 R691.3 [医药卫生—泌尿科学]
  • 相关文献

参考文献10

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  • 7田少江,丁国华,王桂荣,桂元.表面活性蛋白A在大鼠急性肾盂肾炎动物模型中的表达[J].中华肾脏病杂志,2005,21(8):469-472. 被引量：9
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二级参考文献12

  • 1侯芳玉,高庆英,郭超.大鼠急性逆行性肾盂肾炎模型的制作[J].中国实验动物学杂志,1998,8(1):31-34. 被引量：14
  • 2Wright JR.Immunorogulatory functions of surfactant proteins.Nat Rev Immunol,2005,5:58-68.
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共引文献8

同被引文献58

  • 1孙雪峰,叶任高.尿路感染的诊断与治疗──尿路感染的发病机制[J].中国实用内科杂志,2001,21(4):201-202. 被引量：61
  • 2田少江,丁国华,王桂荣,桂元.表面活性蛋白A在大鼠急性肾盂肾炎动物模型中的表达[J].中华肾脏病杂志,2005,21(8):469-472. 被引量：9
  • 3李如职.停留导尿管致尿路感染病原菌分布及耐药性分析[J].广州医学院学报,2005,33(3):55-56. 被引量：2
  • 4Ben Mkaddem S, Chassin C, Vewalle A. Contribution of renal tubule epithelial cells in the innate immune response during renal bacterial infections and ischemia- reperfusion injury. Chang Gung Med J, 2010, 33: 225-240.
  • 5Hu F, Liang W, Ren Z, et al. Surfaetant protein D inhibits lipopolysaccharide-induced monocyte chemoattractant protein-1 expression in human renal tubular epithelial cells: implication for tubulointerstitial fibrosis. Clin Exp Immunol, 2012, 167: 514-522.
  • 6Hung CS, Dodson KW, Hultgren SJ. A murine model of urinary tract infection. Nat Protoc, 2009, 4: 1230-1243.
  • 7Zasloff M. Antimicrobial peptides, innate immunity, and the normally sterile urinary tract. J Am Soc Nephrol, 2007, 18: 2810-2816.
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  • 9Gardai SJ, Xiao YQ, Dickinson M, et al. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell, 2003, 115: 13-23.
  • 10Hawgood S, Ochs M, Jung A, et al. Sequential targeted deficiency of SP- A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol, 2002, 283: L1002-LIO10.

引证文献3

二级引证文献13

中华肾脏病杂志
2009年 第12期

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