期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

干扰素直接抗乙型肝炎病毒作用机制研究的现状 被引量：9

The Present State of Research in Direct Antiviral Mechanism of Interferon on Hepatitis B Virus
原文传递
导出
摘要 干扰素除具有免疫调节作用外,还能通过直接抗病毒作用抑制乙肝病毒(hepatitis B virus,HBV)的复制。干扰素与细胞膜上的受体结合后,通过激活JAK-STAT途径、干扰素调节因子(IRFs)信号传导途径等,产生一系列细胞因子,参与调节HBV增强子Ⅰ和X启动子(EhnⅠ/Xp)的功能,同时诱导宿主细胞产生抗病毒蛋白,作用于HBV复制周期的不同环节而产生直接抗病毒作用。本文主要对这一机制进行综述。 In addition to immune regulation, interferon could suppress hepatitis B virus （HBV） replication through direct antiviral effect. After binding with the receptors on cell membrane, interferon directly inhibits HBV at different steps in HBV replication cycle by activating cell signaling cascades such as JAK-STAT pathway, interferon regulatory factor （IRFs） signaling pathway, and so on, followed by inducing a series of cytokines which are involved in regulation of the function of HBV enhancer Ⅰ / X promoter （Ehn Ⅰ / Xp）. Also, interferon could induce the host cells to produce anti-viral proteins. This review describes the direct antiviral mechanism of interferon on HBV.
作者 刘凤君 唐红
机构地区 四川大学华西医院感染性疾病中心 川北医学院附属医院感染科
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2009年第6期1358-1362,1371,共6页 Journal of Biomedical Engineering
基金 国家自然科学基金资助项目(30571640) 2004年度CMB医学教育与科研基金项目资助(88-486)
关键词 干扰素 乙型肝炎病毒 机制 Interferon Hepatitis B virus （HBV） Mechanism
分类号 R512.62 [医药卫生—内科学]
  • 相关文献

参考文献25

  • 1ROBEK M D, BOYD B S, CHISARI F V. Lamda interferon inhibits hepatitis B and C virus replication[J]. J Virol, 2005, 79(6) :3851-3854.
  • 2WESOLY J, SZWEYKOWSKA-KULINSKA Z, BLUYSSEN H A. STAT activation and differential complex formation dictate selectivity of interferon responses[J]. Acta Biochim Pol, 2007, 54(1) :27-38.
  • 3ZHANG Q, WANG Y, WEI L, et al. Role of ISGF3 in modulating the anti-hepatitis B virus activity of interferon-alpha in vitro[J].J Gastroenterol Hepatol, 2008,23(11) :1741-1761.
  • 4OKAMOTO H, IMAI M, SHIMOZAKI M, et al. Nucleotide sequence of a cloned hepatitis B virus genome, subtype ayr: Comparison with genomes of the other three subtypes [J].J Gen Virol, 1986,67 (Pt 11):2305-2314.
  • 5NAKAO K, NAKATA K, YAMASHITA M, et al. P48 (ISGF-3γ) is involved in interferon-a-induced suppression of hepatitis B virus enhancer-1 activity[J]. J Biol Chem, 1999, 274 ; 28075-28078.
  • 6ALCANTARA F F, TANG H, MCLACHLAN A. Functional characterization of the interferon regulatory element in the enhancer 1 region of the hepatitis B virus genome[J]. Nucleic Acids Research, 2002, 30(9): 2068-2075.
  • 7RANG A, HEISE T, WILL H. Lack of a role of the interferon-stimulated response element-like region in inerferon α-induced suppression of hepatitis B virus in vitro[J]. The Journal of Biological and Chemistry, 2001, 276(5) :3531-3535.
  • 8HALLER Q, KOCHS G, WEBER F. Interferon, Mx, and viral countermeasures [J]. Cytokine Growth Factor Rev, 2007, 18(5-6) :425-433.
  • 9HOVANESSIAN A G. On the discovery of interferon-inducible, double-stranded RNA activated enzymes: the 2'-5' oligoadenylate synthetases and the protein kinase PKR[J]. Cytokine Growth Factor Rev, 2007, 18(5-6):351-361.
  • 10张权,魏来,王燕.ISGF3:IFN-α抗乙型肝炎病毒信号转导机制的重要因子[J].中华实验和临床病毒学杂志,2005,19(2):110-113. 被引量：6

二级参考文献9

  • 1卢圣栋.现代分子生物学实验技术(第2版)[M].北京:中国协和医科大学出版社,2001.444.
  • 2Montalto G, Cervello M, Giannitrapani L .Epidemiology, risk factors,and natural history of hepatocellular carcinoma.Ann N Y Acad Sci,2002,963:13-20.
  • 3Yuen MF, Lai CL.Treatment of chronic hepatitis B.Lancet Infect Dis,2001,1:232-241.
  • 4Pestka S, Langer JA, Zoon KC, et al.Interferon and their actions.Annu Rev Biochem, 1987, 56:727-777.
  • 5Kalvakolanu DV.Alternate interferon signaling pathways.Pharmacol Ther, 2003, 100:1-29.
  • 6Xiong W, Wang X, Liu X, et al.Interferon-inducible MyD88 protein inhibits hepatitis B virus replication.Virology, 2004, 319:306-314.
  • 7Sehgal PB.STAT-signalling through the cytoplasmic compartment:Consideration of a new paradigm.Cell Signal,2000,12:525-535.
  • 8Kisseleva T, Bhattacharya S, Braunstein J, et al.Signaling through the JAK/STAT pathway, recent advances and future challenges.Gene,2002,285:1-24.
  • 9Sebastiano M , Angela DB, Rosa AR, et al.Phospholipase C γ1 overexpression and activation induces by interferon beta in human T lymphocytes: an ISGF3-independent response.Cytokine, 1997, 9: 660-665.

共引文献5

同被引文献57

  • 1姚光弼,张定凤,王宝恩,徐道振,周霞秋,雷秉钧.恩替卡韦抗乙型肝炎病毒剂量和疗效的研究[J].中华肝脏病杂志,2005,13(7):484-487. 被引量：116
  • 2张永.干扰素的分子生物学机制研究进展[J].海峡药学,2007,19(1):7-10. 被引量：9
  • 3WESOLY J, SZWEYKOWSKA KULINSKA Z, BLUYSSEN H A. STAT activation and differential complex formation dictate selectivity of interferon responses [J]. Acta Biochim Pol, 2007 , 54 ( 1 ) : 27 -38.
  • 4LI J, DING S C, CHO H, et a!. A short hairpin RNA screen of interferon - stimulated genes identifies a novel negative regulator of the cellular antiviral responsej J] . MBio, 2013, 4(3): e00385- 13.
  • 5HALLER 0, STAEHELI P, KOCHS G. Interferon - induced Mx proteins in antiviral host defense [J]. Biochimie, 2007, 89 ( 6/ 7): 812-818.
  • 6SILVERMAN R H. Viral encounters with 2', 5' - oligoadenylate synthetase and RNase L during the interferon antiviral response [J]. J Virol, 2007, 81 (23): 12720 -12729.
  • 7ZHU R, ZHANG Y B, ZHANG Q Y, et al. Functional domains and the antiviral effect of the double - stranded RNA - dependent protein kinase PKR from Paralichthys olivaceus [J]. J Virol, 2008, 82 (14) : 6889 - 6901.
  • 8PAOLICELLI D, DIRENZO V, TROJANO M. Review of interferon beta - 1 b in the treatment of early and relapsing multiple sclerosisj J}. Biologics, 2009, 3: 369 -376.
  • 9GUIDOTTI L G, MORRIS A, MENDEZ H, et al. Interferonregulated pathways that control hepatitis B virus replication in transgenic mice [J]. J Virol, 2002, 76 ( 6) : 2617 - 2621.
  • 10LANGEVIN C, VAN DER AA L M, HOUEL A, et al. Zebrafish ISG15 exerts a strong anti - viral activity against RNA and DNA viruses and regulates the interferon response [J]. J Virol, 2013, 87 (18) : 10025 -10036.

引证文献9

二级引证文献31

生物医学工程学杂志
2009年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部