弱视儿童双眼总和视觉诱发电位变化的研究

An investigation on binocular summation response of visual evoked potential in children with hyperopia amblyopia

目的探讨弱视儿童双眼视功能及总和图形视觉诱发电位(P-VEP)反应的特点,评估总和P-VEP反应对双眼视觉功能检测的意义。方法选取80名正常儿童和在南昌大学附属第二医院儿童眼科确诊的远视性弱视儿童151例,进行双眼总和P-VEP检查,分析总和P-VEP反应的特点。正常儿童与弱视儿童的人口基线学特征经统计学分析差异无统计学意义。P-VEP检查方法和刺激条件的选择参照吴乐正等的方法,记录电极的放置按照视觉电生理国际标准化的要求。视力检查采用国际标准视力表,双眼视觉功能检查采用Titmus立体图、同视机三级画片。P-VEP检测结果以双眼反应/单眼反应(B/M)比值作为评价指标。结果弱视组儿童总和P-VEP反应低于正常对照组(t=10.75,P<0.01);不同程度弱视组的B/M值随弱视的严重程度明显减低(F=10.93,P<0.01);无同时视者总和P-VEP与有同时视者比较,差异有统计学意义(t=7.835,P<0.01)。结论总和P-VEP反应作为一种客观指标,可以反映弱视儿童的双眼视功能状况,对其双眼视功能的评价具有一定的价值。

Objective Conventional examination for vision function adopts subjective psychophysics methods.Pattern visual evoked potential（P-VEP）binocular summation response is a new objective way for the test of vision function.But its clinical value in evaluating vision function of amblyopia children is still in controversy.This study was to explore the binocular vision and the feature of P-VEP binocular summation in children with amblyopia and evaluate the significance of P-VEP binocular summation in binocular vision.MethodsThis is a case-controlled study.P-VEP binocular summation response and single ocular P-VEP response was respectively recorded in 151 hyperopia amblyopia children and 80 age-and gender-matched normal children.P-VEP response from children with hyperopia amblyopia was recorded under the corrected vision.The hyperopia amblyopia was diagnosed based on the standard of National Children Amblyopia and Strabismus Prevention and Treatment Working Group.The feature of P-VEP binocular summation was further analyzed and compared with monocular VEP response.Informed consent was obtained from each subject or custodian prior to the trail.ResultsNo significant difference was found in latency between P-VEP binocular summation response and monocular P-VEP response whether amblyopia children or normal children（P〉0.05）.Binocular response/monocular response value in amblyopia children was lower than that in normal children（P〈0.05）.Binocular response/monocular response value in mild or moderate amblyopia children was higher than that in severe amblyopia children（P〈0.05）.Binocular response/monocular response value was significantly reduced in the children with binocular vision than in the children without binocular vision（P〈0.05）.ConclusionP-VEP binocular vision,acting as an evaluation factor,could impartially reflect the function of binocular vision of amblyopia children.